Particularities of Real-Time Polymerase Chain Reaction Technique (RT-PCR) in the Monitoring of Chronic Myeloid Leukemia Patients - A Brief Overview


Kinga Tatar, Hortensia Ionita

Department of Hematology, University of Medicine and Pharmacy “Victor Babeş”, Timişoara



Chronic myeloid leukemia (CML) is a myeloproliferative disorder, characterized by a specific chromosomal aberration, the Philadelphia [Ph] chromosome. The Ph chromosome is the result of a reciprocal translocation between the long arms of chromosomes 9 and 22, t (9;22)(q34;q1