Home Archive Vol.37, No.1, 2011 For Practitioner


Pharmacodynamic and Pharmacokinetic Interactions of Class III Antiarrhythmic Drugs

C.N. Viorel, Florica Popescu

Department of Pharmacology, University of Medicine and Pharmacy, Craiova

Abstract: The desirable and undesirable effects of a drug are generally related to its concentration at the sites of action, which in turn is related to the amount administered (dose) and to the drug's absorption, distribution, metabolism, and/or excretion,  and also drug–drug interactions. The class III antiarrhythmic drugs include amiodarone, sotalol, bretylium, dofetilide, ibutilide and azimilide. Class III antiarrhythmic drugs may interact with other drugs by two major processes: pharmacodynamic and pharmacokinetic interactions. In this review are described the interaction between classes III of antiarrhythmic drugs and other classes antiarrhythmics.

Read entire article