Home Archive Vol.37, No.1, 2011 For Practitioner

FOR PRACTITIONER


Pharmacodynamic and Pharmacokinetic Interactions of Class III Antiarrhythmic Drugs

C.N. Viorel, Florica Popescu

Department of Pharmacology, University of Medicine and Pharmacy, Craiova

Abstract: The desirable and undesirable effects of a drug are generally related to its concentration at the sites of action, which in turn is related to the amount administered (dose) and to the drug's absorption, distribution, metabolism, and/or excretion,  and also drug–drug interactions. The class III antiarrhythmic drugs include amiodarone, sotalol, bretylium, dofetilide, ibutilide and azimilide. Class III antiarrhythmic drugs may interact with other drugs by two major processes: pharmacodynamic and pharmacokinetic interactions. In this review are described the interaction between classes III of antiarrhythmic drugs and other classes antiarrhythmics.

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