Home Archive Vol.40, No.4, 2014 Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

Determination of iNOS-2087A>G Polymorphism in Acute Pancreatitis Patients

V. PĂDUREANU(1), IOANA STREAȚĂ(1), M. IOANA(1), V. Surlin(1), E.F. GEORGESCU(1), CRISTINA MĂRGINEAN(1), A. Săftoiu(1)

(1)Research Center of Gastroenterology and Hepatology, Craiova, ROMANIA

    Abstract: Purpose: To determine whether single nucleotide polymorphism (SNP) of inducible nitric oxide synthase (iNOS) is involved in susceptibility for acute pancreatitis. Material and Methods: Genomic DNA was extracted from blood samples collected from cases of acute pancreatitis (n=110) and normal population controls frequency matched for age and sex (n=232). iNOS – 2087A>G polymorphism was genotyped using TaqMan allelic discrimination assays. The association of the genetic polymorphism with clinical and pathological data of the patients was evaluated. Results: We have found no significant statistical association between this polymorphism and an increased risk of developing acute pancreatitis. Conclusion: In Romanian population, the risk of developing acute pancreatitis is not increased by the presence of iNOS-2087A>G polymorphism.
    Keywords: acute pancreatitis, polymorphism, genotype, iNOS

DOI 10.12865/CHSJ.40.04.03


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Volume 40 Issue 4 2014