Home Archive Vol.40, No.4, 2014 Lung Involvement in Multiple Myeloma - Case Study

Lung Involvement in Multiple Myeloma - Case Study

MIMI NIŢU(1), EMILIA CRIȘAN(1), M. OLTEANU(1), CRISTINA CĂLĂRAŞU(2), Mădălina Olteanu(1), M.R. POPESCU(1)

(1)University of Medicine and Pharmacy, Craiova, Pneumology Department, (2)“Victor Babeş” Hospital of Infectious Diseases and Pneumology, Craiova

    Abstract: Introduction: Mutiple mieloma (MM) cells are rarely found in extramedullary sites. The sites of extramedullary dissemination reported in the literature are spleen, liver, lymph nodes, kidneys, thyroid gland, adrenal gland, ovary, tests, lung, pleura, pericardium, intestinal tract and skin. We report a case in which the myeloma was diagnosed after we discovered the presence of monoclonal plasma cells in the bronchoalveolar lavage fluid (BAL). Matherial and method: a case in which diagnosis was established from bronchoalveolar lavage (BAL) fluid demonstrating the presence of monoclonal plasma cells in Craiova Pneumology Departament. Results: Analysis of BAL fluid for the presence of plasma cells and for cytoplasmic immunoglobulin DNA provides a noninvasive means of establishing the diagnosis. Conclusions: Pulmonary parenchyma is an uncommon site of extramedullary involvement in multiple myeloma. Interstitial lung disease as pulmonary manifestation of multiple myeloma is even rarer; only isolated cases with histological proofs have been reported in the literature.
    Keywords: multiple myeloma, myelomatous pulmonary infiltrate, lung fibrosis

DOI 10.12865/CHSJ.40.04.08


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Volume 40 Issue 4 2014