Home Archive Vol.40, No.4, 2014 Pharmacokinetic profile evaluation of di-μ-hydroxo-bis (quercetinatooxovanadium(IV)) complex

Pharmacokinetic profile evaluation of di-μ-hydroxo-bis (quercetinatooxovanadium(IV)) complex

B.S. VELESCU(1), VALENTINA UIVAROSI(1), ANCA BUZESCU(1), I. SARBU(1), ECATERINA IONESCU(2), VALENTINA ANUTA(1)

(1)”Carol Davila” University of Medicine and Pharmacy, Faculty of Pharmacy, (2)”Carol Davila” University of Medicine and Pharmacy, Faculty of Dental Medicine

    Abstract: The present study was designed to evaluate the pharmacokinetic (PK) properties of di-μ-hydroxo-bis(quercetinatooxovanadium(IV) (HOBQOV) complex, with hypoglycemic and hypolipidemic properties, in rats after a single i.p. dose of 100 mg/kg b.w. The HOBQOV complex pharmacokinetics is described by a bicompartmental model and the plasma concentration decrease is described by two phases that might be correlated to the distribution and elimination processes. The obtained results suggest a PK profile of the complex suitable for a profound distribution in the animal organism with possibility of interaction with the cytosolic enzymes.
    Keywords: HOBQOV, HPLC, pharmacokinetics, bicompartmental model

DOI 10.12865/CHSJ.40.04.06


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Volume 40 Issue 4 2014