Home Archive Vol.41, No.3, 2015 Formulation and In Vitro Evaluation of Alendronate Sodium/PLGA Microspheres for Applications in Bone Related Disorders

Formulation and In Vitro Evaluation of Alendronate Sodium/PLGA Microspheres for Applications in Bone Related Disorders

Andreea-Gabriela Deca(1), IONELA BELU(2), O. Croitoru(3), Maria-Viorica Bubulica(3), C.V. Manda(3), J. Neamtu(3)

(1)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Doctoral School, (2)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department II of Pharmacy, (3)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department I of Pharmacy

    Abstract: Purpose - Bisphosphonates are a group of drugs that can be used in the development of new therapies for bone disorders. Microencapsulation by solvent evaporation is a method that results in microspheres with controlled release of the drug. The purpose of the present study was to include sodium alendronate (AL) in poly (lactic-co-glycolic acid) (PLGA) microspheres with a good encapsulation rate. Furthermore it was intended to obtain a prolonged release of the drug over a period of time. Material and methods - Microspheres were prepared by water/oil/water solvent evaporation method. The microspheres were characterized by FTIR analysis using an Avatar Nicolet spectrophotometer. Both encapsulation ratio and in vitro drug release were assessed by chromatographic analysis. Results - The method chosen for sodium alendronate incorporation resulted in microspheres with a good entrapment efficiency. The in vitro drug release from PLGA/AL microspheres was maintained up to 21 days. This suggests that the microspheres had a sustained releasing tendency. Conclusion - Given the prolonged release, PLGA/AL microspheres may be used in a controlled release system with applications in bone disease treatment.
    Keywords: alendronate sodium/PLGA microspheres, bone disorders, formulation, in vitro

DOI 10.12865/CHSJ.41.03.09


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Volume 41 Issue 3 2015