Home Archive Vol.41, No.3, 2015 Particularities of Renal Manifestations in Chronic Viral Hepatitis

Particularities of Renal Manifestations in Chronic Viral Hepatitis

V.F. Iovanescu(1), C.T. Streba(2), D.O. Alexandru(3), A.F. Constantinescu(1), C.C. Vere(2), I. Rogoveanu(2), E. Moţa(4)

(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania, (2)Gastroenterology Department, University of Medicine and Pharmacy of Craiova, Romania, (3)Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania, (4)Department of Nephrology, University of Medicine and Pharmacy of Craiova, Romania

    Abstract: Introduction: Chronic viral hepatitis represent major health problems worldwide, with an evolution that is sometimes marked by a series of extrahepatic manifestations. Among these, kidney disease may occur, either as glomerulonephritis, and/or renal dysfunction. Material and methods: The purpose of this study was to achieve a complete assessment of the liver and kidney function in a series of patients diagnosed with chronic viral hepatitis, in order to identify a possible kidney disease in this context. 104 patients with chronic viral hepatitis B and C, aged between 25 and 80, were included in the study. These patients were assessed by a series of tests that allowed us to perform a complete evaluation of both liver and kidney function: liver cytolysis enzymes, serum bilirubin, markers of cholestasis, markers of viral infection, urinalysis, albuminuria, electrophoresis of urinary proteins, urea, creatinine, and abdominal ultrasound. Results: Glomerular injury was a rare finding in patients with chronic hepatitis. Patients with chronic hepatitis B had glomerular disease in 5,88 % of cases, while 10 % of the patients with hepatitis C presented this type of renal disease. Acute kidney injury was not identified in our patient group. None of the patients in the hepatitis B study group presented chronic kidney disease. CKD was present in two patients with chronic hepatitis C that had no other associated conditions.
    Keywords: chronic hepatitis B, chronic hepatitis C, extrahepatic manifestations in hepatitis, glomerular injury in hepatitis, acute kidney injury, chronic kidney disease

DOI 10.12865/CHSJ.41.03.06


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Volume 41 Issue 3 2015