Home Archive Vol.41, No.3, 2015 The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα

The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ERα

Oana Sorina Tica(1), A. Comanescu(1), Maria Bogdan(2), D.O. Alexandru(3), A.A. Tica(4), T. Ciurea(5)

(1)Department of Mother and Child, University of Medicine and Pharmacy of Craiova, Romania, (2)Pharmacology Department, University of Medicine and Pharmacy of Craiova, Romania, (3)Research Center for Clinical and Experimental Medicine, Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania, (4)Pharmacology Department, Research Center for Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Romania, (5)Research Center of Gastroenterology and Hepatology, Department of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania

    Abstract: GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in generation of rapid estrogenic answers. A very important fact is that GPER-induced genomic effects are additive to those mediated by “classic” estrogen receptors, but regarding the rapid effects, as we prove in this study, these can be significant different or even antagonistic.
    Keywords: GPER, ERα, myometrium, contraction, G1

DOI 10.12865/CHSJ.41.03.03


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Volume 41 Issue 3 2015