Home Archive Vol.41, No.4, 2015 NOD2 Arg702Trp Polymorphism in Romanian Patients with Gastric Cancer

NOD2 Arg702Trp Polymorphism in Romanian Patients with Gastric Cancer

D.N. Florescu(1), Diana Tudoraşcu(2), F. Burada(3), M.G. Cucu(4), M.E. Ciurea(5)

(1)Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Romania, (2)Internal Medicine II, University of Medicine and Pharmacy of Craiova, Romania, (3)Department of Medical Genetics, Human Genomics Laboratory, University of Medicine and Pharmacy Craiova, Romania, (4)Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova, Romania, (5)Plastic and Reconstructive Surgery, University of Medicine and Pharmacy of Craiova, Romania

    Abstract: Purpose. Our study aimed to assess a possible correlation between NOD2 Arg702Trp (rs2066844) polymorphism and gastric cancer risk in a Romanian population. Material/Methods. A total of 322 subjects (72 patients with gastric adenocarcinoma and 250 healthy controls) were included. Genomic DNA was extracted from blood leukocytes and NOD2 Arg702Trp polymorphism was genotyped by Real-Time PCR using specific TaqMan probes. Results. No statistically significant difference was observed between gastric cancer patients and controls when we compared one genotype with other genotype (the CC genotype serves as reference) (OR 0.45, 95% CI: 0.10 - 2.05) or when we compared allele frequencies (the C allele serves as reference) (OR 0.46, 95% CI: 0.11 - 2.04). We examined separately the association of this polymorphism with tumor site and histologic type and no correlation was found. Conclusion. NOD2 Arg702Trp polymorphism is not associated with gastric cancer risk and further investigations are needed to elucidate the contribution of NOD2 gene in gastric carcinogenesis.
    Keywords: gastric cancer, gene, NOD2 polymorphism, genotype

DOI 10.12865/CHSJ.41.04.03


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Volume 41 Issue 4 2015