Home Archive Vol.41, No.4, 2015 Pegylated Interferon-Induced Sarcoidosis Presenting With Anterior Uveitis in a Patient with Chronic Hepatitis C - Case Report

Pegylated Interferon-Induced Sarcoidosis Presenting With Anterior Uveitis in a Patient with Chronic Hepatitis C - Case Report

Adina Kamal(1), P. Mitrut(1), C.K. KAMAL(2), D.O. Alexandru(3), A. Tica(4)

(1)Internal Medicine Department, University of Medicine and Pharmacy of Craiova, Romania, (2)Department of Family Medicine, University of Medicine and Pharmacy of Craiova, Romania, (3)Department of Medical Informatics, University of Medicine and Pharmacy of Craiova, Romania, (4)Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania

    Abstract: Sarcoidosis is a chronic inflammatory systemic disorder of unknown etiology. It is known to be triggered by an autoimmune process, and is currently recognized as a rare adverse event to interferon therapy for Hepatitis C Virus Infection. Clinical presentation of interferon-triggered sarcoidosis is varied, but ocular manifestation as a first symptom was only once, previously reported. We report the case of a 32 year old woman, infected with hepatitis C, for whom antiviral therapy was initiated. Prior to treatment, the patient had outstanding medical history. Three months from the initiation, patient accused pain and redness of the left eye and mild visual loss. The diagnosis of Interferon induced sarcoidosis was established. We are presenting this case because it illustrates the possibility of sudden and severe complications and we want to emphasize the importance of performing ophthalmological examination in patients treated with pegylated interferon α
    Keywords: interferon, sarcoidosis, side effects, autoimmune, uveitis

DOI 10.12865/CHSJ.41.04.14


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Volume 41 Issue 4 2015