Home Archive Vol.42, No.1, 2016 Assessing Endothelial Dysfunction in Patients with Ankylosing Spondylitis

Assessing Endothelial Dysfunction in Patients with Ankylosing Spondylitis

DIANA RODICA TUDORAȘCU(1), PAULINA LUCIA CIUREA(2), A.F. VREJU(2), ANDREEA BĂRBULESCU(3), R.P. TUDORAȘCU(4), D.C. PÎRVU(1), RALUCA NICULINA CIUREA(5)

(1)Department of Medical Semiology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, (2)Department of Rheumatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, (3)Department of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, (4)Cardiology Department, Emergency County Hospital Craiova, (5)Department of Pathology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova

    Abstract: The objectives proposed were the evaluation of the endothelial dysfunction by ultrasonographic with examination in patients with (AS), the evaluation of the lipid profile of these patients and the identification of some correlations with certain clinical and biological parameters. Material and method: The study has a prospective nature, type case-control, and took place in the Rheumatology Clinic of Emergency County Hospital Craiova and was performed on 140 patients, who were divided in two groups, patients from the population of patients suffering from ankylosing spondylitis and non-inflammatory rheumatic affections assisted in the same period of the research. Study design involved: patients with AS registration, duration of the disease, type of joint damage (axial or peripheral), progression of the disease, activity indices (BASDAI), mobility (BASFI) and severity, therapeutic protocol, complete physical examination, ESR, hs-CRP, level of the glucose in the blood, creatinine, uric acid, complete lipid profile, bonejoint radiological examination, ultrasound examination (2D+Doppler) of the carotid arteries. Results and discussions: endothelial dysfunction was more important in patients with AS and was significantly associated with the inflammatory status-especially with hs-CRP, age, duration and severity of the disease. Results of the study show that patients suffering from AS are included in a high risk class due to the chronic inflammatory status and to the pro-atherogenic lipid profile, mutually reinforcing variables. Conclusions: Patients with AS have a pro-atherogenic status and early atherosclerotic lesions.
    Keywords: AS, inflammation, atherosclerosis

DOI 10.12865/CHSJ.42.01.09 


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Volume 42 Issue 1 2016