Home Archive Vol.42, No.4, 2016 The evaluation of beta-2-adrenoreceptors’expression in normal peritumoral tissue in patients with colorectal adenocarcinoma

The evaluation of beta-2-adrenoreceptors’expression in normal peritumoral tissue in patients with colorectal adenocarcinoma

CRISTINA FLORESCU(1), Georgică-Costinel Târtea(2), C.T. Streba(3), NICOLAE-DANIEL PIRICI(4), ILEANA PUIU(5), ELENA-ANCA TÂRTEA(2), MIRELA GHILUŞI(6), MARIA VICTORIA COMĂNESCU(7), ION ROGOVEANU(3), CRISTIN-CONSTANTIN VERE(3)

(1)Department of Cardiology, University of Medicine and Pharmacy of Craiova, Romania, (2)PhD Student, University of Medicine and Pharmacy of Craiova, Romania, (3)Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania, (4)Department of Research Methodology, University of Medicine and Pharmacy Craiova, Romania, (5)Department of Pediatrics, University of Medicine and Pharmacy of Craiova, Romania, (6)Department of Pathology, County Hospital of Craiova, Romania, (7)Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania

    Abstract: Introduction: The aim of this study is to evaluate the expression of beta-2 adrenergic receptors in the normal peritumoral tissue at the colorectal level, just after the front tumor invasion, in patients with colorectal cancer
    Methods: In this study we analyzed normal peritumoral tissues belonging to 56 patients, who were diagnosed with colorectal adenocarcinoma. These tissues were fixed in paraformaldehyde and paraffinembedded. The immunohistochemical study was done on seriate slides following the hematoxylin and eosin staining, after diagnostic and grading. Correlations were made between beta-2-adrenoreceptors’ expression in the normal peritumoral tissue and the clinical and histopathological parameters of the patients with colorectal cancer.
    Results: There are positive correlations between the expression of beta-2-adrenoreceptors and feminine gender, age group under 50 years, tumor size under 5 cm, tumor invasion T3-4 and tumor metastasis in regional lymph nodes N≥2. By analyzing the expression of beta-2-adrenoreceptors in peritumoral tissue depending on tumor grading one can notice that there are positive correlations between beta-2-adrenoreceptors’ expression and poorly differentiated colorectal adenocarcinoma.
    Conclusions: Positive correlation between this type of receptors in normal glandular epithelium, in the vicinity of tumor invasion front of colorectal neoplasm, and certain clinicopathological features suggests the involvement of tumor microenvironment, which expresses them, in the pathogenesis of this neoplasm.
    Keywords: colorectal adenocarcinoma, receptorii beta-2-adrenergici, clinicopathological features

DOI 10.12865/CHSJ.42.04.01 


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Volume 42 Issue 4 2016