Home Archive Vol.43, No.1, 2017 Hepatitis C Virus Induced Sjogren Syndrome - Clinical and Imaging Features

Hepatitis C Virus Induced Sjogren Syndrome - Clinical and Imaging Features

Stefan-cristian Dinescu(1), PAULINA LUCIA CIUREA(2), F.A. Vreju(2), Daniela Larisa Săndulescu(3), ANCA EMANUELA MUSETESCU(2)

(1)Department of Rheumatology, Emergency County Hospital Craiova, Romania, (2)Department of Rheumatology, Emergency County Hospital Craiova, Romania & University of Medicine and Pharmacy of Craiova, Romania, (3)University of Medicine and Pharmacy of Craiova, Romania & Research Center of Gastroenterology and Hepatology

    Abstract: Primary Sjogren syndrome (SS) is an autoimmune exocrinopathy, in which hepatitis C virus (HCV) infection is considered an exclusion criteria, a highly debated topic, mainly because HCV is viewed as a possible ethiopathogenic factor in the disease onset. We report the cases of two female patients diagnosed with HCV chronic infection, whom developed casual sicca symptoms, parotidomegaly and were later diagnosed with HCV-induced SS. First patient developed only the histopathological criteria of pSS and co-existence of mixed cryoglobulinemia, which is viewed as a HCV-related marker. The second patient developed both histopathological and serological (anti-Ro and anti-La autoantibodies) SS-related markers.
    Keywords: Hepatitis C virus, sjogren syndrome, mixed cryoglobulinemia, ultrasound, sialotomography.

DOI 10.12865/CHSJ.43.01.12 


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Volume 43 Issue 1 2017