Home Archive Vol.43, No.3, 2017 Interleukin-8 mRNA Expression in Locally Advanced Colorectal Cancer Patients

Interleukin-8 mRNA Expression in Locally Advanced Colorectal Cancer Patients

A. BĂRBĂLAN(1), IOANA STREAȚA(2), ELENA TATIANA IVAN(3), IRINA CHERCIU(4), V. ȘURLIN(5), M. IOANA(2), A. SĂFTOIU(6)

(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania, (2)Human Genomics Laboratory, University of Medicine and Pharmacy of Craiova, Romania, (3)Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy of Craiova, Romania, (4)Department of Internal Medicine, County Clinical Emergency Hospital of Craiova, (5)First Clinic of Surgery, County Clinical Emergency Hospital of Craiova, (6)Department of Endoscopy, Gastrointestinal Unit, Copenhagen University Herlev Hospital; Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy of Craiova, Romania

    Abstract: Purpose: Interleukin-8 (IL-8) has been proven to promote progression of malignant tumours and control angiogenesis processes. We aim to determine and compare interleukin-8 (IL-8) gene expression level in colorectal tumors (CCR) and peritumoral samples obtained through endoscopic biopsy. Material and methods: Total mRNA was obtained from both tumoral and peritumoral tissue samples collected from patients diagnosed with colorectal cancer. Through Quantitative Real Time PCR, IL-8 gene expression was assessed in both pathologic tissue and adjacent normal mucosa. Results: In our cohort, IL8 expression was higher in adjacent normal mucosa than in tumoral tissue, in all the samples. Further studies on larger groups are required to validate our results.
    Keywords: Interleukin-8 mRNA, advanced colorectal cancer, endoscopy, preoperative analysis

DOI 10.12865/CHSJ.43.03.04 


All articles in this issue

Volume 43 Issue 3 2017