Home Archive Vol.43, No.3, 2017 P21 Immunoexpression in Actinic Keratosis and Cutaneous Carcinomas

P21 Immunoexpression in Actinic Keratosis and Cutaneous Carcinomas

A. MARINESCU(1), C. MĂRGĂRITESCU(2), A.E. STEPAN(2), ALIS MAGDALENA MARINESCU(3), CRISTIANA EUGENIA SIMIONESCU(2)

(1)PhD Student, University of Medicine and Pharmacy of Craiova, Romania, (2)Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania, (3)Institute of Legal Medicine, Craiova, Romania

    Abstract: Actinic keratosis is a precancerous lesion of the skin with variable rates of transformation into
    non-melanocytic carcinomas. The present study aims to analyze p21 expression in actinic keratosis and cutaneous squamous carcinomas. P21 expression analysis revealed a positive reaction in 63 (71.4%) of the investigated cases. The immunostaining analysis revealed positivity in 82.1% of the studied actinic keratosis cases and in 43.9% of the investigated carcinomas. High scores of immunoreactions were identified only for the well-differentiated and for the carcinomas in initial stages. Association of p21 expression with pre-invasive or well-differentiated invasive lesions in early stages of tumor progression suggests that p21 may be an early event in squamous carcinogenesis.
    Keywords: actinic keratosis, cutaneous squamous carcinomas, p21 immunoexpression

DOI 10.12865/CHSJ.43.03.07 


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Volume 43 Issue 3 2017