Home Archive Vol.43, No.4, 2017 Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line

Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line

FLAVIA MARIA CREŢU(1), B.P. STĂNOIU(2), Catalina Pisoschi(1), Anca Predescu(3), GABRIELA RĂU(4)

(1)Department of Biochemistry, University of Medicine and Pharmacy of Craiova, Romania, (2)Department of Cell Biology, University of Medicine and Pharmacy of Craiova, Romania, (3)Department of Histology, University of Medicine and Pharmacy of Craiova, Romania, (4)Department of Organic Chemistry, University of Medicine and Pharmacy of Craiova, Romania

    Abstract: Two novel 1,4-naphthoquinone derivatives containing salicylic acid and procaine moieties were synthesized and evaluated for their anticancer activity in vitro. The antiproliferative effect was assayed against MDA-MB-231 cells, a human breast adenocarcinoma cell line, using CellTiter-Glo® Luminescent Cell Viability Assay. Both compounds tested proved a growth inhibition effect on this cell line in a dose-dependent manner. Our results showed that the compound with procaine effectively reduces breast cancer MDA-MB-231 cells viability and proliferation at higher concentration while that with salicylic acid had an inhibitory effect at lower concentrations and might be tested as an anticancer agent.
    Keywords: 1,4-naphthoquinone derivatives, anticancer activity, human breast cancer cells

DOI 10.12865/CHSJ.43.04.08 


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Volume 43 Issue 4 2017