Home Archive Vol.43, No.4, 2017 Clinical, Histological and Immunohistochemical Evaluation of Larynx Cancer

Clinical, Histological and Immunohistochemical Evaluation of Larynx Cancer

M.S. CIOLOFAN(1), A.N. VLĂESCU(2), CARMEN-AURELIA MOGOANTĂ(1), Elena Ioniță(3), MIHAELA-ROXANA MITROI(1), F. Anghelina(1)

(1)ENT Department, University of Medicine and Pharmacy of Craiova, Romania, (2)PhD, ENT Department, Doctoral School, University of Medicine and Pharmacy of Craiova, Romania, (3)ENT Clinic, Emergency County Hospital Craiova, Romania

    Abstract: Laryngeal cancer represents the malignant degeneration, of epithelial nature or from the connective tissue, which starts in the constitutive elements of the larynx. Cancer localization in the larynx represents between 1% and 3% of all malignant tumors and approximately 50% of ear, nose and throat (ENT) tumors. Squamous cell carcinoma is the most common form (around 95%) of laryngeal cancer, with high incidence in human males from southern and central Europe, Romania occupying one of the top places. Material and Methods. Our study consisted of 490 patients diagnosed with laryngeal cancer from 2010 to 2016. They have been clinically, histologically, immunohistochemically, genetically, therapeutically and prognostically analyzed. Suspended microlaringoscopy has been the standard, allowing tumor extension evaluation and biopsy. All specimens were microscopically analyzed in standard or special histology stainings. For unclear histology specimens, immunohistochemical stainings were performed. Results and discussions. Histological types have been represented as follows: 31 carcinomas in situ, 17 microinvasive carcinoma, 205 poorly differentiated carcinomas, 138 moderately differentiated carcinomas, 63 well differentiated carcinomas, 8 papillary carcinomas, 1 leiomyosarcoma, 1 chondrosarcoma, 6 basaloid squamous cell carcinomas, 4 verrucous carcinoma, 1 malignant melanoma. Conclusions. The study brings to light the importance of integrated clinical, morphological and genetic evaluation of laryngeal cancer, regarding tumoral invasion grading and establishing an adequate surgical and oncologic treatment. The importance of immunohistochemistry in laryngeal cancer concerns prognosis factors which correlate with the evolution and histopathological degree of the lesion. The analysis of tumor invasion can lead to the development of therapeutic conduct and the establishment of prognostic markers.
    Keywords: laryngeal cancer, carcinoma, immunohistochemistry, histology

DOI 10.12865/CHSJ.43.04.14 


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Volume 43 Issue 4 2017