Home Archive Vol.43, No.4, 2017 Formulation and Characterization of Ciprofloxacin loaded PLGA Microspheres for Applications in Orthopedic Infections

Formulation and Characterization of Ciprofloxacin loaded PLGA Microspheres for Applications in Orthopedic Infections

ANDREEA-GABRIELA MOCANU(1), IONELA BELU(2), O. Croitoru(3), MARIA VIORICA CIOCILTEU(3), C.V. MANDA(3), J. Neamtu(3)

(1)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Doctoral School, (2)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department II of Pharmacy, (3)University of Medicine and Pharmacy of Craiova, Faculty of Pharmacy, Department I of Pharmacy

    Abstract: Purpose-Osteomyelitis is a bone infection that appears as a complication after a fracture or orthopedic surgery. Ciprofloxacin is a broad spectrum antibiotic that can be used in local drug delivery systems for the treatment of bone related infections due to its bactericidal activity against both Gram-negative and Gram-positive bacteria. The purpose of the present study was to include ciprofloxacin in poly (lactic-co-glycolic acid) (PLGA) microspheres. Material and methods-Microspheres were prepared by both water/oil/water (w/o/w) solvent evaporation method and solid/oil/water (s/o/w) dispersion solvent evaporation method. The obtained microspheres were characterized by Fourier Transform Infrared Spectroscopy. High performance liquid chromatography method was deployed to determine the encapsulation ratio. Results-The solvent evaporation method chosen for this experiment resulted in microspheres with good entrapment efficiency. Furthermore the microspheres obtained by the s/o/w method displayed better entrapment efficiency. Conclusion-The particles obtained through the s/o/w technique should be further investigated in order to develop a local drug delivery system.
    Keywords: : ciprofloxacin-PLGA microspheres, solvent evaporation, orthopedic infections, osteomyelitis, local drug delivery

DOI 10.12865/CHSJ.43.04.03 


All articles in this issue

Volume 43 Issue 4 2017