Archive issue

Current Health Sciences Journal

vol. 37 no. 3, 2011

1. Changes of the extracellular matrix components in the salivary glands pathology


The aim of this study is to highlight the state of knowledge on quantitative and qualitative changes and the distribution of the various components of extracellular matrix in salivary glands  chronic pathology as well as in benign and malignant tumors of salivary glands.  Thus, we analyzed the results of several studies in recent years that have followed these changes in matrix structures (in particular collagen, laminin, fibronectin, tenascin, glycosaminglycans and proteoglycans), the specificity of these changes associated with  certain pathological  pro-cesses; and how these elements can be an effective tool for  therapeutic intervention

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2. Immunohistochemical Study in Colon Cancer Patients


Colorectal cancer is an important public health problem; it stands at the top of oncologic pathology, in Romania and in the world; colon cancer is the third most frequent cancer diagnosed in men and women. Immunohistochemistry plays an important role in differentiating tumor types, assessment of aggressiveness and recognizing of metastasis origin. Although the molecular analyses are increasingly used, many therapeutical protocols are still based on histological types and immunohistochemical phenotypes. We present the results of an immunohistochemical study on 120 patients with colorectal cancer

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3. Risk Factors Influencing the Oxidative Stress in Surgical Therapy of Skin Grafts


Recent experimental data sustain that twenty-four hours postburn, mitochondrial outer membrane damage was progressively increased and cytosolic cytochrome-c gradually accumulated to approximately three times more, indicating impaired mitochondrial integrity. Maximal decrease of mitochondrial SOD activity occurred 8 hours postburn, maximal decrease in glutathione peroxidase activity persisted 2–24 h postburn. Lipid peroxidation increased, suggesting burn-induced oxidative stress. Administration of antioxidant vitamin therapy prevents burn-related loss of membrane integrity and antioxidant defense in mitochondria and prevents organic dysfunction. Lipid peroxidation could be measured in mitochondria, by means of malondialdehyde level, which assess oxidative stress. The mitochondrial outer membrane damage and cytochrome-c translocation estimate mitochondrial integrity, and activities of SOD and glutathione peroxidase evaluate mitochondrial antioxidant defense. We used this data for observing the burn wound healing correlated with oxidative stress and antioxidant therapy

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4. Biliary Fistula In Surgery Of Hepatic Hydatid Cyst. Therapeutical And Diagnostic Consideration


Hepatic hydatid cyst remains a condition that involves a high social cost, in particular by higher average length of stay. It is known that the main factor that increases the duration of hospitalization is the development of postoperative complications, of which one is the most frequent postoperative biliary fistula. In this study we attempted to analyze the issues raised by biliary fistula, hepatic hydatid cyst surgery occurred in succession in terms of diagnostic methods and therapeutic possibilities

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5. Flebedema Factor Alleged of Chronic Venous Insufficiency - Clinical and Evolutionary Implications - Study on a Total of 305 Cases


Flebedema is the first and most important symptom of venous circulation insufficiency and usually precede or accompany other manifestations induced of cutaneous venous circulation and/or lymphatic system decompensation. Having as aim the identification of the clinical-evolutional aspects of edema in chronic venous insufficiency we have undertaken a study on 305 patients. Results In the group of patients: prevalence of leg edema of venous origin was 26%; edema of venous origin diagnosed are swelling about 82%; the most frequent risk factors are sedentary life style (33%) and family history of disease (31%); approximately 64% of patients with venous edema are treated

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6. Benefits of Using Sonographic Markers at the Triple Test Ultrasound


Introduction: Part of the SONOSEROSCREEN PROJECT , we study at the end of the first trimester  a group of biochemical and ultrasonographic variables. Regardeless the results obtained, all the patients enrolled in this cohort is subject to a second study in the early second trimester that  encompases the dosage of AFP(+/- Ia), β-hCG, uE3 and an  ultrasonographic exam targeted at precise biometry and fetal morphology. We tried to evaluate the achievable benefits  of assesing several markers that are part of the genetic sonogram and the way they change the risk class. Methods: The markers we chose to pursue in our project were : nuchal fold, nasal bone,  cardiac echogenic foci, short femur, short humerus, presence of echogenic bowel.  All present results markers were integrated in a formula that allowed reasesment of  the risk as published by DeVore and we followed in which way this affected the decision whether to proceed with the amiocentesis or not. Our choice was limited by the fact that this was a retrospective study and so we were forced to choose markers we have routinely looked for in our previous triple test ultrasound exams. Results and conclusion: Using the recalculation of risk for every single case we would have been  able to reduce the amniocentesis rate by 17% and drastically improve the rate of detection for aneuploidies. However the evaluation of all markers and non-automatic recalculation of risk is time consuming and should be used only for cases with intermediate risk at the triple/QUAD test

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7. Researches upon the heavy metals content of Silene alba (Caryophyllaceae) species


The analysis of heavy metals in the leaves and stems of Silene alba species has been performed. The mean levels of heavy metals in vegetal dried samples were in normal limits. Differences depend on the presence of organic compounds with ligand character and on the environmental conditions. The results indicate that there is not any real danger by the possible utilization of some pharmaceutical preparations of Silene albae herba

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8. Considerations Regarding the Optical Properties of the Composite Resin Restorative Materials


The purpose of this study has been to investigate the effects of certain substances frequently used in alimentation on the color stability of the composite resin restorative materials. The research hypothesis was that color stability of the composite resin is affected by the type of composite material used and by the polishing procedure. 14 samples of 5X15X2mm have been prepared from seven universal light curing restorative composite resins. The materials have manipulated and cured using LA 500 Blue Light lamp. A first color determination was done before the introduction of the samples in the dyeing agent with the help of an Easy Shade device. The samples have been splited into two lots each with seven samples. The samples from the first lot have been sectioned into three equal segments. The samples from the second lot have also been sectioned into three equal segments, and in addition to the previous group, their exterior surfaces were processed with a diamond burr. For each type of composite we have introduced a sample in one of the three chosen dyes: red alimentary colorant, coffee and red wine. The color of the samples has been determined again using the Vita Easy Shade device. From clinical point of view the results of this study shows that there are three important factors that matter when we talk about durable aesthetic results: the type of composite resin used for the restoration, the finishing and polishing procedures and the pacients’ alimentation habits. The composite resins with a good representation of the anorganic structure are easier to be polished, therefore they have only slight color modifications. Using plastic matrixes for shaping the exterior surface of the restoration is the best solution for obtaining a very smooth surface. The most significant color modifications have been done by the red wine. Coffee and to a smaller extent the red alimentary colorant have modified the color of the restoration material in a smaller degree

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9. The Management Of Crisis Situations - Medical Involvement


Regardless the cause, succeeding and time, crisis situations are characterized by the absolute need for cooperation between and within institutions to induce an efficient answer. Medical implication is always present and extremely diverse and the integration of medical answer needs knowing the objectives, resources, specific procedures and never the less a good communication between medical and general command. To achieve this, building commanding structures implicated in answering the crisis situation needs to develop towards knowing medical actions and practice often together complex and various scenarios

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10. Ethical Considerations on Human Cloning


Cloning is the process by which a genetically identical copy of a certain bacteria, plant or animal is produced by asexual reproduction. There are two types discussed human cloning: therapeutic cloning and reproductive cloning, more likely to achieve a therapeutic cloning is more accessible in terms of technique, but also less morally problematic. Ethics of human cloning has become an important issue in recent years. Legalize human cloning is in the heart of the debate world, was proposed legalizing therapeutic cloning as the only way to investigate, with chances of success, the basic criterion for funding such programs as the main objective being to find treatments for incurable diseases. The cloning of human organs and their use for transplantation or cloning human beings must be taken into account technical and economic barriers

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