Curr Health Sci J, vol. 36, no. 1, 2010

Current research on breast carcinogenesis

[Review]

Felicia Recareanu(1), Corina Gruia(2),Cristiana Simionescu(3), Alex Stepan(3) (1)


(1) Pathology Laboratory, Slatina Emergency County Hospital,
(2) Pathology Laboratory, Craiova Emergency County Hospital;
(3) Department of Pathology, University of Medicine and Pharmacy


Abstract:

The majority of invasive breast carcinoma is thought to develop over long periods of time from certain pre-existing benign lesions. Subsequent tumor progression is driven by the accumulation of additional genetic changes combined with clonal expansion and selection. Epithelial- mesenchymal interactions are known to be an important factor for the normal development of the mammary gland and for the breast tumorigenesis. Insight into the mechanisms of the causation of cancer by estrogen will be identifed determinants of susceptibility to breast cancer and new targets for prevention and therapeutic intervention.


Keywords:
Brest carcinogenesis; genetics; premalignant lesions



Corresponding:
Felicia Recareanu MD, Pathology Laboratory, Slatina Emergency County Hospital, Romania mail: feliciarecareanu@yahoo.com


DOI 10.12865/CHSJ.36.01.01 - Download PDF