CHSJ

Curr Health Sci J, vol. 36, no. 3, 2010

The Dynamic Of Plasma Lipid Indices In Short Term Treatment With Statins

[Original paper]

C. CAPUCI(1), C. STEFAN(1), D. ALEXANDRU(1), R.CAPUCI(2), MARIA IANCAU(1)


(1)University of Medicine and Pharmacy Craiova,
(2) County Ambulance Service Olt


Abstract:

Statins are a class of drugs and cholesterol-lowering effect demonstrated in reducing cardiovascular mortality. Thus, an increasing number of people with increased levels of serum cholesterol achieved with statin therapy indications. The higher level of current records showing that statins prevent cardiovascular disease may be greater in patients with more pronounced vascular inflammatory process. The study included 102 hypertensive patients, with values of total cholesterol (TC) of ? 4.5 mmol / L (> 200 mg / dL) and LDL-C (low molecular density lipoprotein fraction) ? 2.6 mmol / l ( > 135 mg / dL), which were administered simvastatin, lovastatin and pravastatin in doses of 20 mg / day and 40 mg / day for 12 weeks. He was comparing their effect on lipid indices . The dose of 20 mg / day and 40 mg / day the greatest influence on total cholesterol had a simvastatin (reduction of 21.20% and 28.10% respectively). On triglycerides, the effect varied more, the maximum decrease was caused by simvastatin (16.30%) to 20 mg / day and pravastatin (18.30%) at dose of 40 mg / day. Regarding lowering LDL-C and HDL-C (high molecular density lipoprotein fraction), three remedies have similar effects. The largest increase in HDL-C occurred under treatment with 40 mg / day of lovastatin (10.20%). The study aims to assess the effect of administration of statins is to choose a customized treatment according to individual patient characteristics.


Keywords: statins; hypertension; lipid indices



Corresponding: Camelia Capuci MD, PhD Stud. University of Medicine and Pharmacy Craiova, Str Petru Rares nr. 4, 200456, Craiova, Dolj, Romania


DOI 10.12865/CHSJ.36.03.03 - Download PDF
current issue cover Download cover
Download contents

Journal archive