Curr Health Sci J, vol. 36, no. 4, 2010

Helicobacter Pylori And Gastric Carcinogenesis


Diana Stanculescu (1), Rodica Taslica(2), Cristiana Simionescu(3)

(1) Pathology Laboratory, Tg-Carbunesti Hospital;
(2) Pathology Laboratory, Turnu-Magurele Municipal Hospital;
(3) Department of Pathology, University of Medicine and Pharmacy Craiova


Gastric cancer is the fourth most common cancer worldwide, with a frequency that varies greatly across different geographic areas. The Lauren classification of gastric carcinomas recognizes the intestinal and diffuse types that differ substantially in epidemiology and pathogenesis. The most important etiological factor associated with both intestinal and diffuse type of carcinoma is Helicobacter pylori, recognized as a definite carcinogen for gastric cancer. The complex interrelation between Helicobacter pylori strain, inflammation and host characteristics may directly promote diffuse type gastric cancer or induce a cascade of morphological events, i.e. atrophy, intestinal metaplasia and dysplasia, leading to intestinal type gastric cancer. The sequential process of carcinogenesis involves mutations in oncogenes, tumour suppressor genes and cell cycle and mismatch repair genes.

Helicobacter pylori, carcinogenesis, intestinal type gastric carcinoma, diffuse type gastric carcinoma, molecular events

Diana Stanculescu MD PhD candidate Pathology Laboratory, Tg-Carbunesti Hospital, Romania

DOI 10.12865/CHSJ.36.04.02 - Download PDF