Curr Health Sci J, vol. 36, no. 4, 2010

The Mechanisms Of Urothelial Carcinogenesis: A Literature Review


A.E.Stepan(1), Corina Maria Dochit(2), C. Albita(3), Cristiana Simionescu(1)

(1) Department of Pathology, University of Medicine and Pharmacy of Craiova;
(2) PhD candidate, Pathology Laboratory, Craiova Emergency County Hospital;
(3) PhD candidate, The Department of Legal Medicine, UMP Craiova


The present direction of research activities in bladder cancer case is that to find practical applications of biomarkers utility. Urothelial carcinogenesis represents a complex process which implicates a lot of abnormal biomechanisms, like proliferation, angiogenesis, lymphangiogenesis, apoptosis, loss of the cellular phenotype, extracellular matrix alteration. Every of them can be investigated starting from histopathological features and finishing with biomolecular analysis.

Urothelial carcinogenesis

Assist Prof. A.E.Stepan MD, PhD StudentDepartment of Pathology, University of Medicine and Pharmacy of Craiova; Str Petru Rares nr. 4, 200456, Craiova, Dolj, RomAnia: mail

DOI 10.12865/CHSJ.36.04.03 - Download PDF