CHSJ

Curr Health Sci J, vol. 37, no. 3, 2011

Risk Factors Influencing the Oxidative Stress in Surgical Therapy of Skin Grafts

[Original paper]

NICOLAE CORINA IVONA(1), NOVAC M.(2), VRABETE MARIA(3)


(1)Emergency County Hospital Craiova, Department of Plastic Surgery, University of Medicine and Pharmacy of Craiova;
(2)Department of Anesthesia and Intensive Care, University of Medicine and Pharmacy of Craiova;,
(3)Department of Anesthesia and Intensive Care, Department of Normal and Pathological Physiology, University of Medicine and Pharmacy of Craiova


Abstract:

Recent experimental data sustain that twenty-four hours postburn, mitochondrial outer membrane damage was progressively increased and cytosolic cytochrome-c gradually accumulated to approximately three times more, indicating impaired mitochondrial integrity. Maximal decrease of mitochondrial SOD activity occurred 8 hours postburn, maximal decrease in glutathione peroxidase activity persisted 2–24 h postburn. Lipid peroxidation increased, suggesting burn-induced oxidative stress. Administration of antioxidant vitamin therapy prevents burn-related loss of membrane integrity and antioxidant defense in mitochondria and prevents organic dysfunction. Lipid peroxidation could be measured in mitochondria, by means of malondialdehyde level, which assess oxidative stress. The mitochondrial outer membrane damage and cytochrome-c translocation estimate mitochondrial integrity, and activities of SOD and glutathione peroxidase evaluate mitochondrial antioxidant defense. We used this data for observing the burn wound healing correlated with oxidative stress and antioxidant therapy


Keywords: burn trauma, oxidative stress, malondialdehyde, antioxidants , skin grafts



Corresponding: Nicolae Corina Ivona, MD, PhD student, Emergency County Hospital Craiova, Department of Plastic Surgery, University of Medicine and Pharmacy, Craiova; Str Petru Rares nr. 4, 200456, Craiova, Dolj, RomAnia; e-mail drcorinanicolae@yahoo.com


DOI 10.12865/CHSJ.37.03.03 - Download PDF
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