Curr Health Sci J, vol. 39, no. 2, 2013

Lip Squamous Carcinoma - Epidemiologic, Clinical, Evolutive and Therapeutical Aspects

[Original Paper]


1Dermatholgy Department, University of Medicine and Pharmacy of Craiova, 2Pathology Department, University of Medicine And Pharmacy of Craiova,


Purpose. Squamous carcinoma (SC) of the lip is an infiltrating and destructive malignant epithelial tumor, with high potential for lymphatic and/or blood metastasizes. Lip SC is 15-30% of all SC the cephalic extremity and 1/5 of the upper aerodigestive tract cancers We conducted a prospective study in Dermatology Clinic from Craiova, between 2004-2010, with the aim of highlighting the epidemiological aspects, clinical and therapeutically evolution of patients with lip SC. Material and methods. Study group: 152 patients with lip SC, stages T0, T1N0M0. For each patient we filled an analytical card, including: identification data (name, first name, gender, age), area of residence, risk factors (occupation, smoking, alcohol consumption), the site of cancer, disease history, clinical form, the histopathological result, treatment and therapeutic response. All patients undergone surgery. Results. Most of the patients were male (78,95%), from rural environment (85,53%) and they were smokers (84,21%). The tumor site was predominantly on the lower lip (98,03%) and it was preceded by precursor lesions in 67,10% of the cases. We noticed a clinical polymorphism, and histopathological prevailed the well differentiated form (64,47%). Conclusions. Lip SC affects with predisposition men past 60 years, with prolonged exposure to the sun and who smoke. Lip SC onset occurs frequently on premalignant lesions, especially on chronic keratozic cheilitis, pointing out the importance of early diagnosis and appropriate treatment for preblastomatous cheilitis. Early establishment of treatment of lip SC offers the safety of therapeutic accomplishment. Option for surgical treatment of T0, T1N0M0 lip SC is justified by the very good oncological, aesthetic and functional results in most cases. Surgical treatment of primary T0, T1 lesions, respecting the oncological surgery principles makes it not recommended to "filling in" the results with other therapeutic methods. Patients should be regularly examined for a period of at least three years to capture the moment of occurrence of metastases, or a possible relapse of a lip SC. Actions are needed to educate the population about the risk factors and to detect precancerous lesions and SC of rim in early stage.

lip squamous carcinoma, risk factor. prognostic factor

Patrascu Virgil, University of Medicine and Pharmacy from Craiova, Petru Rares Street, No2-4, 200345, Craiova, RomAnia; e-mail:

DOI 10.12865/CHSJ.39.02.05 - Download PDF