Curr Health Sci J, vol. 39, no. 3, 2013

Histopathological Study of the Urothelial Bladder Carcinomas

[Original Paper]


Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania


Introduction: In this study we analysed the most important parameters necessary for the hystopathologic diagnosis of urothelial carcinoma, a tumor which frequently develops at the vesical urothelial’s level. Material and metods: It is presented a study which contained a number of 150 cases of urothelial carcinoma of the bladder, selected during year 2011. We described histopathological aspects corresponding to the growing pattern, tumoral differentiation and invasion depth, as well as the associated lesions, especially those of the urothelium adjacent to the tumors. Results and discussions: The urothelial carcinoma located at the bladder level had various histopathological features. The evaluation of the cytologic atypia and neoplastic configuration, as well as the identification of atypical mitosis, allowed us to graduate the tumors.The analysis of biopsies allowed us to identify the invasion at muscularis propria level in most cases. The lesions associated with invasive urothelial carcinoma were represented by carcinoma in situ, dysplasia, squamous metaplasia, inflamation. Conclusions: The tumoral differentiation degree was correlated with the growing pattern and also with the invasion depth. Some tumors have few associated modifications, enhancing the complexity of the lesions and posing diagnosis setting problems.

urothelium, carcinomas, histopathology

Alex Stepan, Assistant, MD, PhD candidate, Department of Pathology, University of Medicine and Pharmacy of Craiova, 66 1 May Avenue, 200628 Craiova, Romania; Phone/Fax +40251-599 228, e-mail:

DOI 10.12865/CHSJ.39.03.03 - Download PDF