CHSJ

Curr Health Sci J, vol. 40, no. 1, 2014

Angiogenesis Factors Involved in the Pathogenesis of Colorectal Cancer

[Review]

A. MIHALACHE(1), I. ROGOVEANU(2)


(1)Emergency Department, County Emergency Hospital Slatina;
(2)Department of Internal Medicine, University of Medicine and Pharmacy of Craiova


Abstract:

Colorectal cancer stands at the top of oncologic pathology in the world, and in the same measure in Romania because is the third most frequent cancer diagnosed in men and women. Colorectal cancer develops as a result of mutations in genes that control proliferation and cell death. It was established that in the development of a tumor there is originally a prevascular phase followed by a phase of tumor angiogenesis. In the future it is necessary to develop new clinical protocols that angiogenesis inhibitors are associated with chemo or radiotherapy, conventional or other methods such as immunotherapy and gene therapy.


Keywords: colorectal cancer, angiogenesis, oncogenes



Corresponding: Alexandru Mihalache, Emergency Department, County Emergency Hospital Slatina, 9-11 Crisan St., e-mail: alexandru_mihalache2004@yahoo.com


DOI 10.12865/CHSJ.40.01.01 - Download PDF
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