Curr Health Sci J, vol. 41, no. 1, 2015

Possible role of vitamin D3 on the adipocyte/fibroblast trans-differentiation mediated by pancreas cancer



(1)Laboratory of Physiopathology of Obesity, University Laboratory of Medical Research-Department of Medicine, University of Verona, Italy


In pancreatic tumors, white adipose tissue and metabolic disorders related to adipocytes, are recently reviewed as important co-factors in pancreas pathology. Cell differentiation in pancreatic cancer might involve therefore adipose tissue and factors released by adipocytes should play a fundamental role both in cancer onset and in its progression. Among these molecules, a great interest has been devoted quite recently to the hormonal role exerted by vitamin D3 in pancreatic cancer, particularly its active 1,25 dihydroxylated form. Despite the wide bulk of evidence reporting the chemopreventive role of vitamin D, the mechanism by which active vitamin D3 is able to counteract cancer progression and malignancy is yet far to be elucidated.

vitamin D3, adipocyte, pancreas cancer

Salvatore Chirumbolo, PhD, Head of the Laboratory of Physiopathology of Obesity LURM Est Department of Medicine, University of Verona, Italy Policlinico GB Rossi piazzale AL Scuro 10, 37134 Verona-Italy Tel +390458128456; Fax +390458027403; e-mail

DOI 10.12865/CHSJ.41.01.01 - Download PDF