Curr Health Sci J, vol. 41, no. 1, 2015

Variability of Normal Values of Electroretinogram Parameters Due to Aging in Healthy Individuals

[Original Paper]

ANDREEA C. CORICI(1), D.O. Alexandru(2), OANA M. CORICI(1), MIHAELA PUIANU(3), Maria Iancau(1), A. Stefanescu(3)

(1)University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Department of Physiology,
(2)University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Department of Medical Informatics and Biostatistics,
(3)University of Medicine and Pharmacy of Craiova, Faculty of Medicine, Department of Ophthalmology


Aim- To find normal values of implicit time and amplitudes of full-field electroretinogram and to determine their changes with age in healthy Romanian subjects. Material and Methods- The prospective study included 59 healthy subjects aged between 20 and 80 years old; in the end, we had valid ERG recordings for all tests from 54 subjects. All of the participants underwent full-field ERG, recorded with Metrovision MonPack One system. The implicit times and amplitudes were analyzed for a and b waves in dark-adapted 0.01 ERG, dark-adapted 3.0 ERG, dark-adapted oscillatory potentials, light-adapted 3.0 ERG, and 30Hz flicker ERG according to International Society for Clinical Electrophysiology of Vision (ISCEV) protocols. Results- ERG latency values were bigger in subjects above 50 years old than in younger subjects for b wave in dark adapted 0.01, dark adapted 3.0, light adapted 3.0 and dark adapted 3.0 flicker and for a wave in dark adapted 0.01 and dark adapted 3.0 ERG. There was no significant difference in latency values for dark adapted 3.0 oscillatory potentials between young and old subjects. Because of increased variability, we could not prove that observed differences for amplitudes held statistical significance. Conclusions- This study proves there is a major loss in retinal activity due to aging, most of it being caused by the rod cells delayed response. Also, oscillatory potentials do not seem to be affected by age, and could prove a valuable test to investigate for changes in patients with Diabetes mellitus.

ERG, healthy subjects, Romania, implicit time

Dragos O. Alexandru, M.D., Ph.D., University of Medicine and Pharmacy of Craiova, Petru Rares St., No.2, Craiova-200349, Romania; e-mail:

DOI 10.12865/CHSJ.41.01.04 - Download PDF