Curr Health Sci J, vol. 44, no. 3, 2018

Clinical-Morphological Aspects in Spinal Tuberculosis

[Original Paper]


(1)Doctoral School, University of Medicine and Pharmacy of Craiova, Romania,
(2)Department of Orthopaedics and Traumatology, Clinical CF Hospital of Craiova, Romania,
(3)Department of Orthopaedics and Traumatology, Emergency County Hospital of Craiova Romania,
(4)Department of Radiology and Imaging Sciences, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania,
(5)Department of Pathology, “Carol Davila” University of Medicine and Pharmacy of Bucharest, Romania,
(6)“Victor Babeș” National Institute of Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania,
(7)Department of Orthopaedics and Traumatology, University of Medicine and Pharmacy of Craiova, Romania


Osteoarticular tuberculosis (OATB) Aim: The authors made a clinical morphological assessment of tissue samples from patients admitted in Surgical Departments of the Emergency County Hospital of Craiova, Romania, between 1990 and 2015, proved as presenting tuberculous lesions of the spine in the Department of Pathology of the same Hospital. Materials and Methods: The studied material consisted of bone, joint and sometimes muscle tissue fragments resulted from biopsies or surgical excisions from 7 cases coming out of 54 patients investigated in the above-mentioned period of time, where the established histological diagnosis was tuberculosis (TB). For diagnostic confirmation, Ziehl-Neelsen staining has been used as a rule but, in some cases, immunohistochemistry was also used. Results: TB lesions have prevailed in men and around the age of 50 years. Thoracic segment of the spine was the most involved. Epithelioid and giant Langhans cells dominated the inflammatory cellular population. Necrosis was always present, usually in its classical acidophilic form. Fibrosis was almost always absent. On the whole, the granulomatous reaction was in almost half of the cases hyporeactive and disorganized. Conclusions: The clinical morphological profile of our series is fitting with data described in the literature. Because of its life threatening potential, spinal TB should be investigated thoroughly especially in its morphological features in order to obtain as quickly as possible an etiological diagnosis.

Extrapulmonary tuberculosis, Spine tuberculosis, Bones, Joints

Iancu Emil Plesea, Departments of Pathology, University of Medicine and Pharmacy "Carol Davila" and National Institute of Research-Development in the Pathology Domain and Biomedical Sciences "Victor Babes", Splaiul Independentei, 99-101, Bucharest, 050096, Romania, Doctoral School, University of Medicine and Pharmacy, Str. Petru Rares, Nr.2, Craiova, 200349, Romania, e-mail:

DOI 10.12865/CHSJ.44.03.08 - Download PDF