CHSJ

Curr Health Sci J, vol. 48, no. 2, 2022

Liver Histopathological Changes Related to Intraperitoneal Administration of Salicylic Acid/Fe3O4 Nanoparticles to C57BL/6 Mice

[Original Paper]

B. MINDRILA(1), I. ROGOVEANU(2), S.A. BUTEICA(3), L. CERCELARU(4), D.E. MIHAIESCU(5), M.D. MANESCU(1), I. MINDRILA(4), I. PIRICI(4)


(1)Doctoral School, University of Medicine and Pharmacy of Craiova, Romania;
(2)Department of Gastroenterology, Faculty of Medicine University of Medicine and Pharmacy of Craiova, Romania;
(3)Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Romania;
(4)Department of Morphology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
(5)Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Romania


Abstract:

With a simple synthesis and easy engineering of physicochemical properties, iron oxide nanoparticles (IONPs) have become widely used in multiple biomedical applications. The study of IONPs toxicity has become an important issue, especially as the results reported so far are contradictory and range from lack of toxicity to cellular toxicity. The aim of this study was to evaluate the histopathological changes induced in mouse liver by long-term intraperitoneal injection of low doses of IONPs functionalized with salicylic acid (SaIONPs). The study was performed on C57BL/6 mice that received by intraperitoneal injection (IP), every two days, 0.6ml of SaIONPs aqueous suspension (35mg/kg body weight SaIONPs that contained 20mg/kg body weight of Fe3O4) for 28 days. The results of this study showed that the cumulative dose of 105mg/kg body weight SaIONPs (62mg/kg body weight of Fe3O4) induced histopathological changes in the subcapsular region of the mouse liver, possible by the release of salicylic acid into the peritoneal cavity. The cumulative dose of 244mg/kg body weight SaIONPs (145mg/kg body weight of Fe3O4) induced liver centrilobular necrosis, which requires the use of lower doses in biological applications. However, this may prove to be beneficial in the case of targeted accumulation of SaIONPs.


Keywords: Iron oxide nanoparticles, salicylic acid, toxicity, rat liver, hidropic degeneration.



Corresponding: Sandra-Alice Buteica, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania e-mail: alice.buteica@umfcv.ro


DOI 10.12865/CHSJ.48.02.02 - Download PDF
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