Curr Health Sci J, vol. 49, no. 1, 2023

Evaluation of the Paraoxonase-1 Level in Patients with Acute Pancreatitis

[Original Paper]

R Yildiz(1), A Uyanikoglu(2), C Cindoglu(1), M A Eren(3), I Koyuncu(4)


(1)Department of Internal Medicine, Nusaybin State Hospital, Mardin, Turkey,
(2)Department of Gastroenterology, Faculty of Medicine, Harran University, Turkey,
(3)Department of Internal Medicine, Medical Faculty, Harran University, Sanliurfa, Turkey,
(4)Department of Endocrinology and Metabolism, Faculty of Medicine, Harran University, Turkey


Abstract:

Background. This study, aimed to evaluate the role of paraoxonase-1 (PON-1), in the pathogenesis of acute pancreatitis (AP). PON-1 plays a significant role in antioxidant, anti-inflammatory and antiatherogenic responses and may help predict the severity of AP. Methods. A total of 50 patients with AP and 45 healthy volunteers were included in the study. AP was diagnosed when serum amylase and/or lipase values increased threefold and/or more than the upper limit of normal, together with a complaint of abdominal pain. Modified Atlanta and Ranson scoring were used for AP severity. Results. AP causes were biliary for 35 (70%) patients and idiopathic for 8 (16%) patients, AP developed in 6 (12%) patients after endoscopic retrograde pancreatography, and AP in 1 (2%) patient was a consequence hypertriglyceridemia. No difference in PON-1 level was found between the groups (PON-1=197.06±164.6 and 192.1±111.78, respectively, p=0.86). On the other hand, patients were stratified according to the modified Atlanta (177.5±166.8 for mild to moderate vs. 268.5±64.2 for severe, p<0.018) or Ranson (163.2±133.06 for mild vs. 208.8±158.0 for severe, p<0.016). PON-1 level was significantly higher in patients with severe AP compared to patients with mild and/or moderate disease. Conclusion. Although PON-1 level did not differ in patients with and without AP, PON-1 level increased significantly in parallel with the severity of AP. Thus, PON-1 can be a potential marker for the severity of the disease and can predict prognosis.


Keywords:
Acute pancreatitis, paraoxonase-1, anti-inflammatory



Corresponding:
Cigdem Cindoglu, Department of Internal Medicine, Nusaybin State Hospital, Mardin, Turkey, e-mail: ccindoglu@gmail.com


DOI 10.12865/CHSJ.49.01.03 - Download PDF