CHSJ

Curr Health Sci J, vol. 50, no. 1, 2024

In vitro Assessment of Free Radical Scavenging Effect and Thermal Protein Denaturation Inhibition of Bee Venom for an Anti-Inflammatory Use

[Original Paper]

C.A.G. Florescu(1), E.C. Stanciulescu(2), A. Berbecaru-Iovan(3), R.M. Balasoiu(2), C.G. Pisoschi(2)


(1)Doctoral School, University of Medicine and Pharmacy of Craiova,
(2)Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova,
(3)Department of Pharmacology, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova


Abstract:

Inflammation and the injuries produced by free radicals are interconnected and influence each other. The underlying mechanisms of inflammation are partially attributed to the release of free radicals by immune cells, prooxidants that can also cause protein alteration. This study was performed in order to assess the potential anti-inflammatory effect of two bee venom samples harvested from Apis mellifera. Free radical scavenging capacity was investigated using DPPH and ABTS.+ tests and protective effect on proteins through the inhibitory activity on thermal denaturation of albumin.


Keywords: Bee venom, inflammation, free radical scavenging assay, thermal denaturation of albumin.



Corresponding: Elena Camelia Stanciulescu, Department of Pharmaceutical Biochemistry, University of Medicine and Pharmacy of Craiova, e-mail: camelia.stanciulescu@umfcv.ro


DOI 10.12865/CHSJ.50.01.11 - Download PDF
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