Current Health Sciences Journal
vol. 47 no. 3, 2021
1. An Examination of the Relationship between Fear of Coronavirus (COVID-19) in First Year Nursing Students and Their Attitudes to the Profession
D. Yilmaz(1), D.U. Yilmaz(2)
View online - Abstract - Download PDF An Examination of the Relationship between Fear of Coronavirus (COVID-19) in First Year Nursing Students and Their Attitudes to the Profession PDF
This study was conducted with the aim of determining the fear of coronavirus (COVID-19) and attitudes to the profession in first year nursing students, and examining the relationship between them. The descriptive study was conducted in April and May 2021 with first year students at the Nursing Department of Bursa Uludağ University. The research sample consisted of 156 students who participated voluntarily in the study. A Student Description Form, a Coronavirus (COVID-19) Fear Scale and an Attitude Scale for the Nursing Profession were used to collect research data. It was found that the nursing students included in the study had mean scores of 161.49±19.54 on the Attitude Scale for the Nursing Profession (ASNP) and 17.50±5.87 on the COVID-19 fear scale, and that there was a significant positive correlation between the two scores. The means scores on the ASNP and COVID-19 Fear Scale of female students and of students who experienced fear during the pandemic were significantly higher than those of other students (p<0.05). It was also determined that the attitude scores of students who had chosen the nursing department willingly were significantly higher than those of other students (p<0.05).
2. Colorectal Cancer in County Durham-England a Clinical and Statistical Study
D.S. Ilie(1), M.S. Serbanescu(2), N. Ionovici(3), C.J. Busuioc(4), L. Mogoanta(4)
View online - Abstract - Download PDF Colorectal Cancer in County Durham-England a Clinical and Statistical Study PDF
Colorectal cancer is one of the most frequently occurring malignancies which associates increasing mortality and morbidity rates. According to data provided by the World Health Organization, colorectal cancer deaths account for approximately 13% of all cancer fatalities. The carcinogenesis of this type of malignancy is a very complex process characterized by various molecular changes which in turn are influenced by factors likes sex, diet, intestinal microbiota, exposure to environmental factors, hosts’ immune response and also genetic factors. Our study looked at a total number of 1024 patients, which were all diagnosed with colorectal cancer in a hospital in the north of England, a country that is known for both a high prevalence of this type of cancer but also its robust screening programmers. In our analyses, we concluded that this type of malignancies affected mostly males, aged between 60 and 80. The most commonly affected regions were the rectum, the sigmoid colon and also the cecum. The majority of colorectal cancers (51%) were diagnosed by GPs (general practitioners) or other medical specialties; 43.55% of all cases presented as surgical emergencies and 5.47% were diagnosed through national screening programs. Majority of tumors were diagnosed in late stages, mainly T3 and T4 whilst in was observed that rectal cancers were mainly diagnosed in T2 and T3 stages.
3. Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years
C. Pereira(1), M. Martis(1), R. D'Souza(1), L.F. Tauro(1)
View online - Abstract - Download PDF Correlation of Clinicopathological Features of Breast Cancer with Molecular Subtypes Taking Ki-67 into Consideration: Single Institution Experience Over 5 Years PDF
Background. Molecular classification of breast cancer is commonly done to determine response to therapy and cancer prognosis. Aim of the study was to compare prevalence of molecular subtypes of breast cancer in our institute using immunohistochemistry, including Ki-67, and correlate it with clinical and pathological prognostic factors. Results. 300 cases of invasive breast cancer were included in the study. Average age at time of diagnosis was 44 years and average size of tumor was 3.4cms. Invasive ductal carcinoma was the most common histological type (75.3%). The most common molecular subtype was triple negative (34.3%) followed by Luminal B (33.4%), luminal A (17%) and Her-2 positive (15.3%). Large size and poorly differentiated tumors were predominantly triple negative tumors while lymph node metastasis was most commonly seen in Her-2 positive tumors. Conclusion. Molecular subtype of breast carcinoma should routinely be done for all cases of carcinoma breast as it allows to identify aggressive tumors and target therapy accordingly.
4. Hepatitis C Virus Infection and the New Therapeutical Approach
C.M. Danilescu(1), M.C. Pirlog(2), I. Rogoveanu(3)
View online - Abstract - Download PDF Hepatitis C Virus Infection and the New Therapeutical Approach PDF
Hepatitis C virus represents one of the most important public health problems nowadays. Several epidemiological studies have shown a continuous increasing rate of prevalence and incidence with severe consequences in terms of mortality. During the last decades, the treatment of the liver infection has evolved, and now there are available new therapies with better side-effect’ profiles and bigger efficiency. The needs for more therapeutically efficacy also stand behind the numerous comorbidities associated to the liver disease, and also for assuring better quality of life for patients and their families.
5. Hip Joint Abnormalities During Midstance in Osteoarthritic Patients
C. Statescu(1), B.I. Gavrila(2), A. Deaconu(3), R.M. Traistaru(4),T.A. Balseanu(1)
View online - Abstract - Download PDF Hip Joint Abnormalities During Midstance in Osteoarthritic Patients PDF
Osteoarthritis is one of the most debilitating diseases in Europe affecting the lower limb joints, especially the hip and knee, having a bad influence on gait in the long run as well. Rehabilitation physicians use gait in order for the whole body to be seen in ensemble, and through midstance as moment of gait to also take predilection to falls into consideration. Goniometry is the quantifiable measure of a rehabilitation treatment by measuring the range of motion of each treated joint and studied during time. The patients that volunteered to be part of this study have been divided into four groups, depending on the level of osteoarthritis present at the lower limb joints: hip, knee, both hip and knee osteoarthritis or control group with no osteoarthritis, have been asked to walk for a few times and the video recordings were uploaded into the Angles App where we measured the lower limb joint angles during midstance. Patients with knee osteoarthritis present a more extended hip on both dominant and non-dominant sides compared to the ones with hip osteoarthritis, hip and knee osteoarthritis or control group. The results can be explained through the body’s kinematic chains that link the knee and hip, hip and pelvis during the midstance phase in the sagittal plane. A physician can use a video goniometry app in order for him to thoroughly evaluate an osteoarthritic patient as well as follow him or her during the entire course of treatment.
6. Aging and Vascular Compliance in Hypertensive Patients Mirrored in Routine Investigations
R. Balan(1,3), C. Ferdoschi(1), E. Balasescu(1,2), D.A. Ion(1,2)
View online - Abstract - Download PDF Aging and Vascular Compliance in Hypertensive Patients Mirrored in Routine Investigations PDF
The global prevalence of arterial hypertension is increasing. Due to its consequences, hypertension is a leading cause of morbi-mortality. In this regard, awareness of the importance of diagnosis as well as proper treatment of hypertension is mandatory. Objectives: This study aims to analyze vascular compliance and different pressure characteristics depending on age, along with highlighting some clinical-paraclinical correlations in people diagnosed with hypertension. We used usual laboratory analyzes and the blood pressure values obtained using ABPM/24 hr, in addition to highlighting the impact of age on those parameters. Materials and methods: The sample comprises of 99 adults diagnosed with hypertension. We divided them into 2 groups, according to age: cases sample: 52 patients (age> 60 years old) and control sample: 47 patients (age< 60 years old). Results: In the control group, RDW was correlated with the general and diurnal systolic and diastolic hypertonicity indexes and the platelet count was positively correlated only with the morning surge. The dipping profile correlates negatively with RDW. In the elderly, all three systolic blood pressure parameters are influenced by ESR and also correlate negatively with HDL, with an inverse proportional relationship. Statistically significant correlations were found between blood glucose and diurnal systolic and diastolic hypertonicity indexes. Mean Pulse Pressure correlates in the elderly with HDL (negative correlations) and in the young with RDW (positive correlations). Conclusions: Vascular compliance can be estimated with the help of HDL in the elderly and RDW in young people, considering the influence of the two parameters on pulse pressure.
7. A Study on Dermatomyositis and the Relation to Malignancy
A.D. Tudorancea(1), P.L. Ciurea(1), A.F. Vreju(1), A. Turcu-Stiolica(2), C.E. Gofita(1), C. Criveanu(1), A.E. Musetescu(1), S.C. Dinescu(1)
View online - Abstract - Download PDF A Study on Dermatomyositis and the Relation to Malignancy PDF
The idiopathic inflammatory myopathies (IIM) are a group of heterogeneous systemic diseases which include as main subtypes: polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). The key feature of IIMs is the muscle weakness, accompanied by a characteristic skin rash in DM patients. The overall risk for malignancy in IIM is higher compared to the age-and sex-matched general population. Most epidemiologic studies have included only PM and DM patients and reported consistently higher rates of malignancy in DM. Most common types of cancer in DM are adenocarcinoma of the lung, ovary or gastrointestinal tract, melanoma and non-Hodgkins lymphoma. The highest risk for malignancy is seen in the first year after DM diagnosis. Multiple disease features have been linked to the development of cancer in DM. These include: older age, male sex, skin necrosis, Gottron sign, heliotrope rash, dysphagia, low complement C4, lymphocytosis, poor response to corticosteroids and rapid disease progression. Our study included 23 patients with DM, divided into two groups based on the association of malignancy, in order to compare clinical and demographic features, laboratory markers and analyze characteristic of cancer development.
8. Macroscopic Changes in Oral Mucosa and Hygiene Indicators in Smokers
G.V. Popa(1,2), L. Mogoanta(3), O. Badea(4)
View online - Abstract - Download PDF Macroscopic Changes in Oral Mucosa and Hygiene Indicators in Smokers PDF
Smoking is the most important factor affecting the oral cavity by components born in the tobacco combustion process and acting directly on the oral mucous membranes, dental arch and indirectly on the teeth support. Recent studies show the tobacco action on the oral cavity, manifestations in the form of gingivitis, bacterial plaque, dental plaque, papillary bleeding at drilling, periodontitis. Purpose of the study. In this study, we have set out to assess the macroscopic modifications of oral cavity on smokers. Materials and Methods. The participants in the study were divided into two groups, the first group of smokers with a smoking period over 5 years and the control group of nonsmokers. The patients in the two groups underwent a physical examination and an objective clinical examination, the resulting data being compared with the control group. Results. For the bacterial plaque indicatorin the smoker group there was obtained a mean value of 35.68±12.45, compared to a mean value of 16.32±6.61 for the nonsmoker group, the dental plaque indicatorfor the smoker group had a mean value of 2.24±1.02, higher than the one in the nonsmoker group, namely 0.94±0.68, and for the drilling bleeding indicator we obtained a mean value of 19.54±7.89 in the nonsmoker group, which is lower than that in the smoker group, namely 42.86±14.93. Conclusions. Smoking is a cause that maintains and aggravates the periodontal disease, including the risk of periodontitis, allowing the aggravation of gingivitis, considered a reversible surface inflammation of the gum mucosa which, by accumulation of dental plaque, the dental plaque accompanied by incorrect oral hygiene, favors the progression to periodontitis.
9. The Frequency of Dental Materials Use for Fixed Prostheses in a General Dental Practice
A.M. Caracas(1), H.O. Manolea(2), I. Mitrut(1), R.E. Caracas(1), D.A. Tartea(1), M.A. Draghici(1), C.M.L. Nistor(1), D.O. Alexandru(3)
View online - Abstract - Download PDF The Frequency of Dental Materials Use for Fixed Prostheses in a General Dental Practice PDF
This retrospective study aimed to evaluate the frequency of dental materials use for fixed prosthesis depending on the location of the teeth, the restorative prosthetic type, the age and sex of the patients from a dental practice in Essen, Germany. The analysis of the collected data showed that zirconia is currently the most common material for making dental fixed prostheses, a larger number of prosthetic elements for women and a significant increase for these restorations at ages over 40 years. Most of the prosthetic elements were made in the mandibular molar area, with an increased frequency of zirconia bridges in the mandible, while for the upper jaw the number of crowns was higher. Zirconia was more frequent used in female patients and in the age group 60-69.
10. Complexity of Gait Angle Measurements at the Ankle Joint During Midstance in Patients with Osteoarthritis
C. Statescu(1), B.I. Gavrila(2), A. Deaconu(3), R.M. Traistaru(4), T.A. Balseanu(1)
View online - Abstract - Download PDF Complexity of Gait Angle Measurements at the Ankle Joint During Midstance in Patients with Osteoarthritis PDF
The evolution of rehabilitation treatments can be quantified through goniometric measurements. Thus, a video goniometer, and an app-based goniometry program can be both useful and a reliable method of obtaining a data base through which we can see if a certain rehabilitation treatment works out for our patients and during times such as the Covid-19 pandemic, a telemedicine approach can be done. Midstance is a sub-moment of the gait pattern, important in the stability of the lower limb, but that can also direct us towards a patient prone to falls. Osteoarthritis is a disease that causes high disability because of the cellular degradation that also affects normal gait. Four groups of subjects: subjects suffering from hip osteoarthritis, knee osteoarthritis, hip and knee osteoarthritis and control group, have been filmed and recorded their midstance joint range of motion in the Angles App. The dominant limb has been proven to have a more extended ankle in the hip osteoarthritis group, compared to knee osteoarthritis, hip and knee osteoarthritis or control group. Females have presented a more extended ankle, wearing high heels for a long period of time can be the cause of that. Subjects with knee osteoarthritis have presented a more flexed ankle in the dominant limb compared to the ones suffering from hip and knee osteoarthritis or control group. The ankle joint can also have its range of motion measured with a video goniometer, helping us compare results in between sessions of rehabilitation in osteoarthritic patients.
11. Metabolic Impact of Diabetes Mellitus Type 2 in Hepatitis C Virus Infected Patients
M.S. Popescu(1), D.M. Firu(1), R. Mitrut(2), D.N. Margaritescu(3), A.M. Kamal(1), V. Padureanu(1), P. Mitrut(1)
View online - Abstract - Download PDF Metabolic Impact of Diabetes Mellitus Type 2 in Hepatitis C Virus Infected Patients PDF
Objective: Patients with chronic hepatitis C are subjected to a greater risk of cardiovascular disease and difficult to control diabetes mellitus type 2 (T2DM) comparatively to people that have never contracted Hepatitis C Virus (HCV). We aimed to investigate the impact of T2DM on HCV patients with the help of Fibromax test results compared to nonT2DM patients, and the metabolic differences between the 2 study groups. Our long term goals are to observe the long term impact of achieving systemic virusologic response (SVR) by means of Direct-Acting antivirals (DAA) between the 2 cohorts. Research Design and Methods: We selected a lot of 200 patients with HCV that will undergo interferon-free DAA-based antiviral treatment for HCV and we used the results of the Fibromax Test to compare the biological parameters of T2DM and nonT2DM patients. RESULTS Among patients with T2DM compared to NonT2DM there is a significant correlation on Steatotest, NashTest, GGT, Glycemia, body weight, height and BMI. Test also showed that 15,5% of the test group had elevated glycemia, indicating the probability of developing diabetes in the future. Conclusions: Our results suggest that HCV patients that also have T2DM are subjected to a combined higher risk of accelerated steatosis development, steatohepatitis, added difficulty in controlling glycemic levels. All these previous elements combined with a prevalence for patients to be overweight have a negative metabolic impact. Eradication of HCV with the help of DAA is important in order to help improving the metabolic impact of diabetes on steatosis, steatohepatitis. An added benefit is better management of glycemic control by decreasing insulin use and eliminating one risk factor of T2DM.
12. The Potential of Helianthin Loaded Into Magnetic Nanoparticles to Induce Cytotoxicity in Glioblastoma Cells
A. Costachi(1), C.E. Cioc(1), S.A. Buteica(1), D.E. Tache(1), S.A. Artene(1), A.S. Sevastre(1), O. Alexandru(1), L.G. Tataranu(2), S.O. Popescu(1), A. Dricu(1)
View online - Abstract - Download PDF The Potential of Helianthin Loaded Into Magnetic Nanoparticles to Induce Cytotoxicity in Glioblastoma Cells PDF
The central nervous system tumors are the most common solid tumors in adults.. Unlike other types of cancers, brain cancer is much difficult to treat because of the blood-brain barrier (BBB) that prevents drug substances from crossing it and accessing the brain. Different types of methods to overcome BBB have been used in vivo and in vitro, of which the use of nanoparticle-mediated delivery of therapeutic drugs is particularly promising. In the present study, we used iron oxide magnetic nanoparticles (NPs) as carrier system for helianthin (He/NPs) to treat cancer cells derived from glioblastoma. An early passage cell cultures (GB1B), established in our laboratory from tissue obtained from a patient diagnosed with glioblastoma, was used. The cells were treated with different concentrations of NPs or HeNPs and then cell proliferation was measured at 24, 48 and 72 hours. Our results showed that the treatment with NPs was well tolerated by glioblastoma cells, the viability of the cells increased very slightly after the treatment. Furthermore, we demonstrated that helianthin loaded Fe3O4 magnetic nanoparticles induced cytotoxicity in human glioblastoma cells. The treatment with HeNPs induced dose and time dependent.
13. A Cross-Sectional Study to Assess Thyroid Function in Infants and Children in a City from South-Western Romania
C.M. Vasile(1,2), A.E. Ghenea(3), A.L. Udristoiu(4), S. Udristoiu(4), M. Popescu(5), V. Padureanu(6), D.O. Alexandru(7)
View online - Abstract - Download PDF A Cross-Sectional Study to Assess Thyroid Function in Infants and Children in a City from South-Western Romania PDF
Thyroid hormones are critical regulators of growth, myelination of the nervous system, metabolism, and organ function. The most prevalent endocrinopathies in childhood are related to thyroid disorders. Thyroid problems in children and adolescents have a significantly different etiology and clinical presentation than in adults. Thus, pediatric medical care involves an understanding of the unique features of thyroid function and dysfunction during childhood and adolescence. The etiology and clinical manifestations of thyroid disorders in children and adolescents are vastly different from those in adults. The particular aspects of thyroid function and malfunction in childhood and adolescence are hence part of pediatric medical therapy. To prevent persistent nervous system damage and developmental problems, it is vital to recognize and treat thyroid dysfunction in neonates as early as possible. The purpose of the research was to understand more how children's thyroid problems function, structure, and prevalence. The research examined 30 children under the age of 16 years who had symptoms that were linked to thyroid problems. In addition to demographic and family information, thyroid ultrasounds and blood samples for the detection of T3, T4, and TSH were obtained. Females surpassed males by a small majority (2.33:1 ratio).Out of the total children included in the study, 14(46.7%) cases for autoimmune thyroiditis, 2(6.67%) cases for congenital hypothyroidism, 1(3.33%) case for hyperthyroidism, 1(3.33%) case for hyperthyroidism-Graves disease, 8(26.7%) cases for hypothyroidism and 4(13.3%) cases for subclinical hypothyroidism.
14. Relationship between Serum Leptin Values and Abdominal Circumference Assessed in the First Trimester of Pregnancy in Obese Women
C. Tabacu(1), M.M. Manolea(2), A.L. Dijmarescu(2), M.S. Serbanescu(3), M.V. Boldeanu(4), L. Novac(2)
View online - Abstract - Download PDF Relationship between Serum Leptin Values and Abdominal Circumference Assessed in the First Trimester of Pregnancy in Obese Women PDF
Higher serum leptin values have been correlated with several complications of pregnancy, while the abdominal circumference (AC) is an anthropometric measurement usually used to diagnose abdominal obesity. For this study we compared serum leptin levels between two groups of pregnant women: those with abdominal obesity (AC>88cm) and those without abdominal obesity (AC<88cm), diagnosed at the beginning of pregnancy. Serum leptin levels were obtained through measurements performed between 11-14 and 28-32 weeks of gestation. Higher serum leptin levels were found in the group of pregnant women with abdominal obesity comparing to the group without abdominal obesity, but a positive correlation between abdominal circumference and the leptin values was found only at 11-14 weeks of pregnancy. Our study showed that a simple measurement of AC performed at the beginning of pregnancy may predict the average serum levels of leptin throughout the gestation period. A better understanding of the role of leptin during development is needed to make us able to know how maternal-placental-fetal leptin exchange influence the fetal development.
15. Evaluation of Body Fat Composition and Digit Ratio (2D:4D) in Polycystic Ovary Syndrome in Adolescents
V. Deepika(1), P. Preethy(2)
View online - Abstract - Download PDF Evaluation of Body Fat Composition and Digit Ratio (2D:4D) in Polycystic Ovary Syndrome in Adolescents PDF
Polycystic ovary syndrome (PCOS) is a common endocrine disorder. It is a multi-factorial disease, of which excess androgen and android fat pattern is previously reported. The digit ratio (2D:4D) is the ratio of length of index finger to the length of ring finger which epitomize the prenatal gonadal hormone exposure. So, the present study aimed to evaluate body fat composition and digit ratio among young adolescent PCOS patients and normal individuals. It was an analytical cross-sectional study. Based on the inclusion and exclusion criteria, 48 subjects (24 in each group), that is, control and PCOS group were identified and baseline characteristics were recorded. Body fat composition was evaluated using body fat analyzer and digit ratio (2D:4D) was measured using the digital Vernier calipers. Student’s t-test was used to assess differences between means. In the present study, BMI was significantly increased among the PCOS group compared to the normal (p=0.03). The 2D:4D digit ratio was significantly lower (p=0.001) among the PCOS group. Body fat (p=0.05) and visceral fat (p=0.01) were significantly higher among the PCOS group. There was negative correlation between BMI, body fat, visceral fat and digit ratio, but was not statistically significant while body fat, visceral fat and BMI showed significant positive correlation. The present study indicates that the 2D:4D digit ratio is decreased, while BMI, body fat and visceral fat are significantly increased among the PCOS group. Digit ratio and body fat can be used to evaluate the high risk PCOS adolescents and plan early interventions.
16. Frequency of Bone Augmentation Materials Use in a General Dental Practice
R.E. Caracas(1), H.O. Manolea(2), I. Mitrut(1), A.M. Caracas(1), A.I. Salan(3), M.A. Draghici(1), A.M. Rica(4)
View online - Abstract - Download PDF Frequency of Bone Augmentation Materials Use in a General Dental Practice PDF
This retrospective study aimed to evaluate the frequency of bone augmentation materials used for implant or periodontal surgical treatment depending on the age and sex of the patients from a dental practice in Essen, Germany, but also the implants dimensions and respectively the stage and progression grade of the periodontitis. The analysis of the data showed that bone augmentation materials are used much more frequently in the implant surgical cases (43,33%) compared to periodontal surgical cases (13,33%). While the correlations with sex and age were less obvious, the use of bone augmentation materials in the implant surgical cases was correlated with the use of shorter implants, while their use in the periodontal surgical cases was correlated with the stage 3 periodontitis.
17. The Impact of Covid-19 on Surgical Training and Outcomes: A Multicenter Experience (Greece and Romania)
K. Sapalidis(1), S. Pantea(2), S. Laskou(1), V. Surlin(3), V. Magra(1), D. Vilcea(4), E. Paschou(1), V. Manaki(1), A. Goganau(3), C. Nica(2), C. Mirea(4), D. Vasileiou(1), P. Roulia(1), S. Patrascu(3), P. Radu(5), I. Kesisoglou(1), V. Strambu(5), T. Ciurea(6)
View online - Abstract - Download PDF The Impact of Covid-19 on Surgical Training and Outcomes: A Multicenter Experience (Greece and Romania) PDF
Background. The COVID-19 pandemic has posed unprecedented challenges to health systems worldwide-in delivering care to patients and in maintaining training of their care providers. Surgical specialties have particularly struggled to maintain sufficient levels of training as we have seen significant reductions in the number of surgical beds, operating lists and redeployment of surgical staff to COVID-19 departments or Intensive Treatment Units. Methods. Comparison of the number of surgical operations performed between January 1st 2019 and December 31st 2020 in 3 surgical departments in Romania (Craiova, Timisoara and Bucharest) and 1 surgical department in Thessaloniki, Greece. Cases were compared on a month-to-month basis, both elective and emergency operations were included and divided into three main categories based on severity (Minor, Medium, Major). Results. Between 2019 and 2020, there was a 37.04% decrease in the number of surgical procedures, 36.95% for open procedures and 37.20% for laparoscopic procedures. Statistically significant overall reduction was observed in all three centers for both open and laparoscopic operations. In all centers, a statistically significant reduction in medium severity procedures was also observed. Conclusion. Globally felt detrimental effect on surgical training, patient contact and mental wellbeing reflected similarly across surgical specialties in both countries.
18. Rare BRCA2 Mutation and MSI-H in Male Patient with Aggressive Stage III Colorectal Cancer, Case Report and Literature Review
V. Ghimpau(1), B.S. Ungureanu(2), D.I. Gheonea(2), C. Lungulescu(1), C.V. Lungulescu(3)
View online - Abstract - Download PDF Rare BRCA2 Mutation and MSI-H in Male Patient with Aggressive Stage III Colorectal Cancer, Case Report and Literature Review PDF
Colorectal cancer is the third most common malignancy worldwide. We report the case of a 66-year-old man diagnosed with stage III B colorectal cancer who underwent radical surgery, adjuvant chemotherapy and subsequently developed hepatic metastases. Two months following metastasectomy, PET-CT scan revealed liver metastases with metabolic activity. The patient was started on FOLFIRI chemotherapy regimen in combination with cetuximab, and achieved stable partial remission 7 weeks after starting the treatment. NGS and IHC testing of the surgically removed tumor revealed MSI-H/dMMR, and NRAS/KRAS wild type status, moderate positive (30%) expression of PD-L1 protein, along with BRCA2 mutation.
19. The Unusual Presentation of a Single Case of Synchronous Metastatic Clear Cell Renal Cell Carcinoma to the Gallbladder: A Case Report and Literature Review
G.T. Patterson(1), A. Ullah(2), I. Elhelf(3), R. Madi(4), S.K. Kavuri(2), N.A. Karim(5)
View online - Abstract - Download PDF The Unusual Presentation of a Single Case of Synchronous Metastatic Clear Cell Renal Cell Carcinoma to the Gallbladder: A Case Report and Literature Review PDF
Clear cell renal cell carcinoma, accounts for approximately 70% of all adult renal tumors. This disease is well known for its high metastatic potential, with estimates of 25-50% of patients reporting metastasis to distant structures. However, there have only been several reported cases in medical literature describing hematogenous spread to the gallbladder, with the majority occurring metachronously, in males, and with multiple metastases. This case report follows an extremely unique presentation in a 60-year-old female. Although the patient did not exhibit the usual signs and symptoms or meet the typical demographics seen with metastatic renal cell carcinoma, it should find a place on the differential diagnosis list when a gallbladder lesion is detected on imaging during the initial staging and/or restaging in patients with renal-cell carcinoma.
20. Conservative Management of a Jejuno-Jejunal Intussusception in a Patient with Severe Haemophilia A
F. Salma(1), W. Soukaina(1)
View online - Abstract - Download PDF Conservative Management of a Jejuno-Jejunal Intussusception in a Patient with Severe Haemophilia A PDF
A 29-year-old man with severe haemophilia A developed right lower quadrant pain. He was diagnosed with jejuno-jejunal intussusception, and he was managed conservatively with an infusion of plasmatic factor VIII, resulting in resolution of symptoms, and reduction of the jejuno-jejunal intussusception, and complete regression of hematoma. This case highlights a rare clinical manifestation in patients with haemophilia, and also indicates the effectiveness of factor VIII instead of exploratory surgery for intramural hematoma
21. Subcutaneous Emphysema as a Life-Threatening Complication of Metastatic Renal Cancer: A Case Report
E. Gambuti(1), F. Alfano(1), F. Fabbian(1), B. Perna(1), M. Guarino(1), R. De Giorgio(1)
View online - Abstract - Download PDF Subcutaneous Emphysema as a Life-Threatening Complication of Metastatic Renal Cancer: A Case Report PDF
Subcutaneous emphysema (SE) could present as an emergency situation requiring appropriate management because of possible serious complications. While the diagnosis can be well established, its classification and treatment are not yet standardized. Herein we report the case of SE occurred in a young man after positioning of a thorax drainage because of a hydro-pneumothorax developed as a consequence of pulmonary metastases from clear cell renal carcinoma. Since there are no data correlating anatomo-clinical categorization with outcome and treatment of patients with SE, a "tailored- treatment" may be considered.
22. Long COVID Mimicking Interstitial Lung Disease: A Case Series
N. Goel(1), N. Goyal(1), R.Kumar(1)
View online - Abstract - Download PDF Long COVID Mimicking Interstitial Lung Disease: A Case Series PDF
Interstitial lung diseases (ILD) can occur due to various known or unknown causes. They usually present with dry cough and exertional dyspnea. On radiology usual findings are ground glass opacities (GGO’s), reticular shadows, nodules etc. Some patients after acute COVID-19 (coronavirus disease 2019) suffer from persistent symptoms/manifestations. These have been called ‘Long COVID’. Long COVID also has radiological features like GGO’s, nodules and reticulations. Also, patients without the history of acute COVID-19 also can present with ‘Long COVID’. In the present case series, we describe three such cases with no history of having suffered from COVID-19, presenting with ILD like features and diagnosed as Long COVID. We infer from these cases that ‘Long COVID’ can mimic clinically and radiologically the ILD’s. Hence, emphasizing the fact that in the present COVID-19 pandemic situation, ‘Long COVID should be a differential diagnosis to be considered while making a new diagnosis of ILD.
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