CHSJ

Curr Health Sci J, vol. 35, no. 1, 2009

Histopathological Study of Renal Cell Carcinoma

[Original paper]

A. C. Stinga(1), Alina Simona Stinga(1), Cristiana Simionescu(2), C. Margaritescu(2), M. Cruce(3)


(1) Department of Pathology Emergency County Emergency University Hospital, Craiova;
(2) Department of Pathology, University of Medicine and Pharmacy, Craiova;
(3) Department of Celular and Molecular Biology, University of Medicine and Pharmacy, Craiova


Abstract:

Background. Prognostic markers for renal cell carcinoma (RCC), such as tumor stage, grade, and necrosis or microvascular invasion are useful for determining appropriate follow-up and selecting patients for adjuvant therapy. Hence, the objective of the current study was to evaluate these pathological variables and also we attempted to establish possible correlations between them. Patients and Methods. Seventy-two patients from the Pathology Department of Emergency County Hospital no. 1 from Craiova, Romania, were included in this retrospective study. Age, sex, histologic subtype, pT stage, Fuhrman grade, tumor necrosis and microvascular invasion were determined in all cases. Results. Clear cell, papillary, chromophobe carcinomas and renal oncocytoma accounted for 53 (73.61%), 12 (16.66%), 3 (4.16%) and 3 (4.6%) cases, respectively. Fuhrman grade 2 and pT3 stage were predominant features, tumor necrosis was identified in one third of investigated tumors and microvascular invasion in 9 tumors (12.5%).Conclusions. Most tumors were clear cell type and had a predilection for G2 and pT3 categories, instead papillary form, the second as frequency, had higher values regarding grading and tumor necrosis, but lower stage. Tumor necrosis correlates with higher grade and tumor stage.


Keywords: renal, carcinoma, clear, papillary, chromophobe, oncocytoma



Corresponding: A. C. Stinga , MD, Emergency County Emergency University Hospital, Craiova, Tabaci 1 St., 200456, Craiova, Dolj, Romania


DOI 10.12865/CHSJ.35.01.09 - Download PDF
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