CHSJ

Archive issue

Current Health Sciences Journal

vol. 39 no. 2, 2013

1. Cellular Basis of Bronchial Inflammation in Chronic Obstructive Pulmonary Disease (COPD)

F. PETRESCU1, V. BICIUSCA1, OCTAVIA ILEANA PETRESCU2, C. M. FORTOFOIU1

Chronic obstructive pulmonary disease (COPD) is a major health problem, characterized by a progressively and irreversible change in lung function. This is associated with chronic airways inflammation, structural remodeling, and alveolar wall destruction. Inflammatory cells may contribute to mucus hypersecretion, the airways remodeling by the secretion of proteases, cytokines, and fibrotic or mitogenic growth factors. Neutrophils, macrophages, and T cells have implicated in many studies, indicating their roles in the chronic inflammatory process of airways. The identification of risk factors, inflammatory mediators, and understanding their interactions are important for the development of anti-inflammatory treatments, that may reduce the inflammation and alleviate the clinical symptoms of COPD.

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2. New Approaches to Celiac Disease in Children

ILEANA OCTAVIA PETRESCU1, SIMONA COSOVEANU1, F. PETRESCU2

The celiac disease represents an important chronic digestive disorder due to the consequences of the malabsorption syndrome and the complications which may appear during adulthood. The paper focuses on recent epidemiological data, and presents both the typical and atypical disease forms and the necessity for investigating the whole range of risk groups for the diagnosis of the silent and latent forms of disease.

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3. Markers of subclinical atherosclerosis and cardiovascular risk in young adults horizontally infected with HIV-1 during infancy

FLORENTINA DUMITRESCU1, A CUPSA1, DINA-MARIA CUPSA2, DANIELA MARINESCU3, ANDREEA CRISTINA STOIAN1, L GIUBELAN1, IRINA NICULESCU 1, CRISTINA IOCU 2

Objectives: to evaluate the markers of subclinical atherosclerosis and to identify a potential cardiovascular risk (CVR) profile in young adults horizontally infected with HIV-1 during infancy. Methods: prospective randomized study, carried out between 01 January 2010 and 30 June 2010, on 56 HIV infected persons (PIH) parenterally infected with HIV-1 during 1988-1990, following antiretroviral treatment (ART), under surveillance of Craiova HIV/AIDS Regional Center, Romania. Variables followed: personal history and clinical data, traditional and additional CVR factors, metabolic, immunological and virological parameters, inflammation markers (high-sensitivity C reactive proteine- hs-CRP), ultrasound data regarding carotid intima-media thickness (IMT). Twenty-six HIV-seronegative young adults were assigned as control group (CG) for metabolic parameters, hs-CRP and IMT. Results: general characteristics of the group: average age = 20.82 ± 1.1 years, equal gender distribution, 47 PIH (83.93%) classified as clinical and/or immunological AIDS, 26 PIH (46.43%) with CD4>500/mm3, 40 PIH (71.43%) with undetectable RNA-HIV when evaluated, average ART duration = 9.09 ± 3.2 years, average number of ART regimens = 3.2 ± 1.63, 40 PIH (71.43%) experienced to protease inhibitors (PIs). In PIH – hs-CRP = 2.17 mg/l, equivalent with a moderate CVR, statistically different compared with CG (p<0.0001); IMT = 0.76 ± 0.12 mm in PIH vs 0.6 ± 0.11 mm in CG. From the traditional CVR factors dyslipidemia levels were higher in the PIH group vs CG (p<0.0001). In PIH, linear analysis of the evaluated parameters identified direct correlations between hs-CRP- erythrocytes sedimentation rate (ESR) (p=0.04), number of ART regimens and PIs exposure (p=0.007), IMT (p=0.000) and HIV-RNA (p=0.000) and also between IMT–triglycerides (p=0.004), PIs exposure (p=0.004), CD8+ (p=0.0000) and HIV-RNA (p=0.001). Conclusions: young PIH have had an average value of hs-CRP suggestive for a moderate CVR. Elevated triglycerides, ESR, CD8+, HIV-RNA values and long period of PIs exposure should be components of a CVR profile in young adult infected with HIV-1 during infancy.

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4. Study of the Oral Formulation of Metoprolol - the Release From Prolonged Release Formulations

IONELA BELU2, C ALECU1, I MANOLESCU1, O POPESCU2, V ANUTA1, I MIRCIOIU3, R SANDULOVICI3

The purpose of our study was to realize some pharmaceutical forms with extended release of Metoprolol, included in hydrophilic metocel or carbopol media (10%, 20% and 30% hydrophilic polymer), and to test the kinetic of Metoprolol release of these formulations in two distinct phases: 60 minutes in hydrochloric acid 0.1 N (simulating the gastric environment), and four hours in phosphate buffer solution pH 6.8 (simulating the intestinal environment). From the obtained data, it was found that for metocel forms the rate of Metoprolol release was much lower than the carbopol forms. It is well known that the kinetics of drug release from hydrophilic matrix is controlled by diffusion, as long as the hydrated polymer remains intact. Therefore, we found a linear relationship between the quantity of released drug and time’s square root, which shows that Higuchi’s equations, valid for explaining the release from insoluble matrix, can by also applied to hydrophilic matrix.

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5. Lip Squamous Carcinoma - Epidemiologic, Clinical, Evolutive and Therapeutical Aspects

VIRGIL PATRASCU 1, RALUCA CIUREA 2

Purpose. Squamous carcinoma (SC) of the lip is an infiltrating and destructive malignant epithelial tumor, with high potential for lymphatic and/or blood metastasizes. Lip SC is 15-30% of all SC the cephalic extremity and 1/5 of the upper aerodigestive tract cancers We conducted a prospective study in Dermatology Clinic from Craiova, between 2004-2010, with the aim of highlighting the epidemiological aspects, clinical and therapeutically evolution of patients with lip SC. Material and methods. Study group: 152 patients with lip SC, stages T0, T1N0M0. For each patient we filled an analytical card, including: identification data (name, first name, gender, age), area of residence, risk factors (occupation, smoking, alcohol consumption), the site of cancer, disease history, clinical form, the histopathological result, treatment and therapeutic response. All patients undergone surgery. Results. Most of the patients were male (78,95%), from rural environment (85,53%) and they were smokers (84,21%). The tumor site was predominantly on the lower lip (98,03%) and it was preceded by precursor lesions in 67,10% of the cases. We noticed a clinical polymorphism, and histopathological prevailed the well differentiated form (64,47%). Conclusions. Lip SC affects with predisposition men past 60 years, with prolonged exposure to the sun and who smoke. Lip SC onset occurs frequently on premalignant lesions, especially on chronic keratozic cheilitis, pointing out the importance of early diagnosis and appropriate treatment for preblastomatous cheilitis. Early establishment of treatment of lip SC offers the safety of therapeutic accomplishment. Option for surgical treatment of T0, T1N0M0 lip SC is justified by the very good oncological, aesthetic and functional results in most cases. Surgical treatment of primary T0, T1 lesions, respecting the oncological surgery principles makes it not recommended to "filling in" the results with other therapeutic methods. Patients should be regularly examined for a period of at least three years to capture the moment of occurrence of metastases, or a possible relapse of a lip SC. Actions are needed to educate the population about the risk factors and to detect precancerous lesions and SC of rim in early stage.

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6. Study On The Frequency And Values Of Sanguine Eosinophilia In Children Admitted With Parasitary Diseases

CRISTINA SINGER1, POLIXENIA STANCU1, SIMONA COSOVEANU1, ALINA BOTU1, CAMELIA CRISTEA2, DIANA BACIU2

The authors carried out a retrospective study on the frequency, levels and relative and absolute mean values of sanguine eosinophily in children admitted with various parasitary diseases within the sanitary units in Craiova and in the Pediatric Clinic of Fundeni Clinical Institute, Bucharest, over a period of 12 years. The study group consisted of 2,198 children, aged 0-16 years: 1,226 with diseases caused by protozoa – 1,195 intestinal giardiasis and 31 acquired Toxoplasmosis; 754 with diseases caused by nematodes - 169 Ascaridiasis, 470 Oxyurasis, 23 Trichocephalosis and 92 Trichinellosis; 50 with diseases caused by cestodes - 23 Hydatidosis and 27 Himenolepidosis; 168 with different associated parasitoses. For processing the data we used statistical-mathematical methods: arithmetic mean (Am) and standard deviation (± Sd).

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7. Hyperhomocysteinemia in Pregnancy and the Type of Anesthesia

ALICE GAVRILA1, LILIANA NOVAC2, MARIA-MAGDALENA MANOLEA2, LORENA DIJMARESCU2, DANIELA CERNEA1

Hyperhomocysteinemia is due to genetic and acquired changes in the metabolism of homocysteine. During pregnancy, women with MTHFR genetic disorders and hyperhomocysteinemia present a high risk of thromboses; therefore they undergo antepartum anticoagulant treatment with low molecular weight heparin.Complications of pregnancy related to thrombosis and the fact that birth, as far as time is concerned, is unpredictable, lead to unique challenges when it comes to choosing the type of anesthesia. In this article we intend to discuss what type of anesthesia is suitable for patients with hyperhomocysteinemia diagnosed.

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8. The esthetic exigency and the limits of the complex prosthetic reconstruction

M.R.POPESCU1, L.CHIRIGIU2, L.P.DRAGOMIR1

This article describes the evaluation and prosthetic treatment planning in which aesthetic requirement represented a major challenge and the rebalancing dento-facial somatosensory required optimal planning of each stage of treatment. Assuming that any dental unit deserves to be preserved for a period as long as possible on the arcade trying to implement a concept that can provide predictable prosthetic rehabilitation to restore optimally the physiological function.

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9. Bcl2 gene expression in breast tumors

SIMONA DANIELA NEAMTU1, IULIA TUDORASCU1, C. MARGARITESCU1, C.TAISESCU1 , C.TUDORASCU2, MIHAELA NICULESCU1, G. GAMAN1

Breast cancer is the most common form of woman cancer, it is a major problem for health, being the most common neoplasia with an increased incidence of morbidity and mortality. The overall growth of this form of malignancy of mammary gland disorder requires understanding the various mechanisms involved in tumorgenesis. The appearance of a very rich material and permanent concern of medicine on breast cancer incidence is justified by the occurrence of this type of cancer in young people, both women and men. The diversity of geographical spread of disease requires finding the means of limiting the expansion of therapeutic and aggravation of its evolution. In the aim of increasing life expectancy, genetic studies, the recognition of the intrinsic mechanisms intervening between cells and enter in triggering alteration cell populations involved in healing and therapeutic strategies aimed at discovering, in doing so, they gained a large share.

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10. Clinical Evolutive Aspects and Physical Rehabilitation in Patients with Chronic Gout

OTILIA ROGOVEANU, RODICA TRAISTARU, IRINA CHERCIU, ROXANA POPESCU

Gout is a metabolic disease caused by a disturbance of the metabolism of purines. Urate hyperproduction, primary or secondary to other diseases, leads to hyperuricemia found in most of the gout patients. In the advanced diseases stages, the patients presents secondary arthrosis with the subchondral sclerosis and outbreaks of osteophytes. The extra-articular manifestations (renal, biliary) are quite frequent and sometimes invalidating.

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11. Intrajejunal migration of adjustable gastric band: a case report

K SAPALIDIS, L LIAVAS, N PANTELI, E KOSMATOPOULOS, I ANASTASIADIS, S CHARALAMBIDES, I KESISOGLOU, N TZIRIS

Introduction. Laparoscopic gastric banding is a first line bariatric procedure that is performed worldwide and can achieve substantial weight loss. Despite its many advantages, as the least invasive bariatric procedure, it has several complications like gastric prolapse, stoma obstruction and migration of the gatstric band. Rarely are these complications life threatening, but re-operation is usually the only treatment. Case presentation. We report a rare case of intrajejunal migration of an adjustable gastric band that was placed laparoscopically four years ago. Conclusion. Gastric band migration is a rather common complication of laparoscopic gastric banding, but intrajejunal migration is very rare and requires high clinical suspicion, close follow-up and thorough pre-operative investigation so as to avoid intraoperative surprises and retrieve the displaced gastric band safely.

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12. Study on the Importance of the Complementary Exams for the Dento- Parodontal Changes to the Patiences with Occlusal Trauma

L.P. DRAGOMIR1, M.CARAMIZARU3, T. COMANESCU3, C. DAGUCI2, M.R.POPESCU1

The diagnosis of the occlusal disorders of the dento-maxillary is a delicate stage, but of great importance in establishing the functional rehabilitation of the dental arches. Occlusal disorders occur as a result of dental anomalies of number, odontal coronary lesions, dental migration, edentulous, gnatoprotetic devices improperly executed, changes of the occlusion parameters, and secondary musculoskeletal and joint disorders.The difficulty in the diagnosis, is that any trauma occurring in any component of the stomatognathic system may lead to occlusal dysfunction. Meanwhile, occlusal dysfunction can cause symptoms in all dento-maxillary structures. Recent research on the phenomenon of occlusal trauma etiology showed major difficulties in determining the exact causes and evolution of the phenomenon itself. This paper highlights the importance of usage in practice of the registration and transfer systems, also the important role of the radiological examination in detecting and highlighting the phenomenon of occlusal trauma.

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13. The Red Plan

LUCIANA ROTARU1, C CIULU2

‘’Emergency situation is an nonmilitary exceptional event who’s proportions and intensity is threatening for the population’s health, environment, cultural and material values .To reestablish normality ,are necessary urgent actions and measures, supplementary resources and unitary management of implicated forces[11].’’ At the same time, Emergency Medical System is itself an in hospital and outside of hospital complex gearing ,with an unitary call center, build from professional and voluntary teams, framework on the idea of developing successive competence levels in emergency response and to adapt itself to certain crisis needs.

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