CHSJ

Curr Health Sci J, vol. 35, no. 4, 2009

Influences Exercised By The Intensity Of The Oxidative Stress Over Wounds Healing In Surgical Therapy Of Breast Cancer

[Original paper]

I. TUDORASCU BRUJAN(1), C. MARGARITESCU(2), M. NOVAC(3), C. SIMIONESCU(2), C. FOARFA(2), M. VRABETE(1)


(1)Dept. of Physiopathology;
(2)Dept. of Pathology;
(3)Dept. of Anesthesia-Intensive Care, University of Medicine and Pharmacy, Craiova


Abstract:

The objectives of our study were: Determination of the plasmatic oxidative status over the patients with operated breast cancer (CS). Assessment of the ratio between the intensity of the induced S.Ox (tumour + surgical act) and the plasma antioxidant potential. Evidencing of parameters, allowing elaboration of a prediction with regard the quality of the post-operation wound cure. Methods: We investigated 32 patients with breast cancer (CS) and 37 healthy patients (witness lot), 69 cases, in total. We have calculated the total anti/oxidant potential, of plasma (TAOP), measured the concentration of total peroxides from plasma and calculated the ratio between the two values, which is expressed as an index of oxidative stress (ISO). These values are used in order to appreciate the oxidative status of plasma. We achieved four groups of study, considering the morphopathological aspect of tumours and the prognosis over the quality of wound healing, post-surgery. In order to explain the psychopathological mechanisms involved in healing the surgery wounds done on the neoplastic field, we checked the evolution of clinical parameters: clinical: wounds appearance, umorals interactions between the residing cells and those migrating from the blood vessels into the wound tissues. We associated to the conventional therapy, post-surgery a diet with exogenous oxidants (C vitamin, selenium, and beta carotene) and we noted down the features of wound healing, after 3/6 weeks post/operation, up to 2-4 years of life, as appropriate. Outcomes: TAOP has been reduced, the index of the oxidative stress significantly increased at the patients with operated CS, who had a faulty wound healing. The additional exogenous anti/oxidants have different effects, from none effect, to the patients with a lipids and glucides rich diet up to defaultless healing and improvement of the general clinical condition. Conclusions: Reduction of the oxidative stress intensity has a positive role in wound healing and for this reason the administration of some exogenous anti/oxidants could influence the evolution of the general condition of the patients operated for breast cancer (CS), with a favourable sense , for life.


Keywords: oxidative stress, cathepsin D, TAOP, IOS, peroxides, breast tumor, antioxidants



Corresponding: Dr. Iulia Tudorascu,Dept. of Physiopathology, University of Medicine and Pharmacy. Craiova , ibrujan@yahoo.com


DOI 10.12865/CHSJ.35.04.12 - Download PDF
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