CHSJ

Curr Health Sci J, vol. 35, no. 4, 2009

Dissolution of Pentoxifylline from Extended Release Formulations. Researches Concerning Development of a Biorelevant Test

[Original paper]

G. IONICA(1), F. RADULESCU(1), D. MIRON(1), V. ANUTA(1), C. MIRCIOIU(1), I. BELU(2)


(1)Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Bucharest;
(2)Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova


Abstract:

Paper presents results of a pharmacokinetics study concerning pentoxifylline and its main metabolites after administration of extended release formulation of Trental 400 mg and correlation of this pharmacokinetics with in vitro dissolution test results of parent drug. In order to establish most relevant in vitro test, dissolution was performed in different experimental conditions (stirring rate and dissolution medium). Correlation was linear and very good. Generalization of correlation to rate of appearance of metabolites in plasma proved that this process could be well correlated with dissolution. Most relevant test was finally found to be the release in water medium, in conditions of a high stirring rate – 100 rpm.


Keywords: biorelevant test, pentoxifylline and its principal metabolites, dissolution, in vivo–in vitro correlations, apparent absorption



Corresponding: Professor Constantin Mircioiu, Pharm., PhD, Department of Biopharmacy, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia Street, 020956 Bucharest, Romania; Phone +4021-318 07 50, e-mail: constantin.mircioiu@yahoo.com


DOI 10.12865/CHSJ.35.04.13 - Download PDF
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