CHSJ

Curr Health Sci J, vol. 35, no. 4, 2009

Correlations Between Chorial Villositary Vasculogenesis and Ultrasound Morpho-Functional Markers of The Trofoblast In The Normal Pregnancy

[Original paper]

L. NOVAC(1), M. NICULESCU(2), D. ILIESCU(3), M. MANOLEA(1), S. TUDORACHE(3), R. CAPITANESCU(3), N. CERNEA(3)


(1)Department of Obstetrics and-Gynecology, University of Medicine and Pharmacy, Municipal Emergency University Hospital, Craiova;
(2)Department of Anatomy and Pathology, University of Medicine and Pharmacy, Municipal Emergency University Hospital, Craiova;
(3)Department of Obstetrics and-Gynecology, University of Medicine and Pharmacy, County Emergency University Hospital, Craiova


Abstract:

Introduction. The placental vasculogenesis process appears only in the time of the embryo developement and forms the primar vasculary substratum, the first capillary vessels developing in the days 18 – 20 from the fecundation, phenomena that are necessary for the normal evolution of the pregnancy. At the same time, at the level of the implantation site, the ultrasonographic investigation of the trofoblast has shown specifical changes correlated with the gestational age. Matherial and method. We have investigated 47 pregnant women with the gestational age between 5 and 12 weeks, which had legal abortion on request. The patients were echographically monitored until the time of the curettage, particulary by the trofoblastic thickness at the implantation site. The material resulted after the curettage has been histologically studied, the histological and echographical evaluation of the cases being made according to the gestational age. Results and discutions. It has been accomplished a gestational histological grading by establishing some specific elements of the villositary developement related to the gestational age, that has been correlated with the dates from the ultrasonographical evaluation. Conclusions. The trofoblastic vasculogenesis undergoes stadial phenomena specific to the first trimester chronology and the trofoblastic thickness at the implantation site level may be correlated with the gestational age. The correlations between those histologic and imagistic characteristics of the placentation at the implantation site may allow a better understanding of the phenomena that have their roots at this level, and it is necessary to have additional studies for determining if the changes of this phenomena are associated with the spontaneous abortion.


Keywords: vasculogenesis; trofoblast; ultrasound



Corresponding: Prof. Liliana Novac MD, PhD, Department of Obstetrics and-Gynecology, University of Medicine and Pharmacy Craiova, Str Petru Rares nr. 4, 200456, Craiova, Dolj, RomAnia; mail: liliana.novac@gmail.com


DOI 10.12865/CHSJ.35.04.07 - Download PDF
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