CHSJ

Curr Health Sci J, vol. 35, no. 4, 2009

Histopathological Study of the precursor Lesions of the Ductal Invasive Breast Carcinoma

[Original paper]

G.L. FOTA(1), C. SIMIONESCU(2), C.V. GEORGESCU(1), N. PATRANA(1), M. MUNTEAN(3), A. STEPAN(2)


(1)Laboratory of Pathology, Emergency Clinical Hospital of Craiova;
(2)Morphopathology Discipline, Medical School, Univerisity of Medicine and Pharmacy of Craiova;
(3)Laboratory of Pathology, Emergency Clinical Hospital of Slatina


Abstract:

The precursor lesions of the ductal invasive breast carcinoma are a heterogeneous group of lesions that raise problems in defining, classifying and diagnosing them. These lesions include the usual ductal hyperplasia, flat epithelial hyperplasia (Ductal Intraepithelial Neoplasia grade 1A), atypical ductal hyperplasia (Ductal Intraepithelial Neoplasia grade 1B), and ductal carcinoma in situ (13, 16). There are three histopathological grades of the ductal carcinoma in situ: low grade (Ductal Intraepithelial Neoplasia grade 1C), intermediate grade (Ductal Intraepithelial Neoplasia grade 2) and high grade (Ductal Intraepithelial Neoplasia grade 3) of malignity (13). We focused on the distribution of the precursor lesions of the ductal invasive breast carcinoma within the pathology of mammary gland, their association with ductal invasive breast carcinoma, the shares of the age categories and sexes, as well as their histopathological study. The predominant lesion of the ductal invasive breast carcinoma was the usual ductal hyperplasia. We found the usual ductal hyperplasia as being the only precursor lesion also microscopically diagnosed at men. In the studied period, we have not found flat epithelial hyperplasia cases. The least frequent precursor lesion was the atypical hyperplasia. Comedocarcinoma was the most frequent in association with the ductal invasive carcinoma. This study aims to bring new references to those existing or to confirm the data from the pathology literature.


Keywords: usual ductal hyperplasia, atypical hyperplasia, ductal carcinoma in situ



Corresponding: GEORGIANA LUMINITA FOTA, e-mail: entergoshift78@yahoo.com


DOI 10.12865/CHSJ.35.04.09 - Download PDF
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