CHSJ

Curr Health Sci J, vol. 36, no. 3, 2010

Influence Of Some Dissolution Enhancing Agents On The Pharmacokinetic Profile Of Meloxicam Delivered From Hydrophilic Ointments

[Original paper]

A.S. SEVASTRE(1), R. CAZACINCU(2), D. LUPULEASA(3), I. BELU(1), F. POPESCU(1)


(1)Faculty of Pharmacy, University of Medicine and Pharmacy, Craiova;
(2)Faculty of Pharmacy,”Ovidius” University, Constanta;
(3)Faculty of Parmacy, ”Carol Davila” University of Medicine and Pharmacy, Bucuresti


Abstract:

Meloxicam, a very poorly soluble in water selective COX2 non steroidian antiinflamatory drug, was included in Carbopol 990 hydrogels using dissolution enhancing agents. Carbopol 990 is a high molecular weight polymer, easily soluble in water even at low concentrations, with increased viscosity, transparency and filmogen gel forming properties. To increase the solubility of Meloxicam, in this study we used: Tween 80, Triethanolamine and polyethylene glycol 400 (PEG 400). The kinetic profile of Meloxicam in vitro release from pharmaceutical formulations was studied using Franz diffusion cell. Methylcellulose artificial membrane was used as diffusion membrane.


Keywords: Meloxicam, ointments, Franz diffusion cell, enhancers



Corresponding: Ani-Simona Sevastre, PhD stud, Faculty of Pharmacy, University of Medicine and Pharmacy Craiova, Str Petru Rares nr. 4, 200456, Craiova, Dolj, Romania


DOI 10.12865/CHSJ.36.03.09 - Download PDF
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