CHSJ

Curr Health Sci J, vol. 36, no. 4, 2010

Epidemiology And Risk Factors In Carcinomas Of The Large Bowel

[Update]

C.L. GRUIA(1), C. STREBA(2), C.M. DOCHITA(1), C.C. VERE(2), A.G. IONESCU(2)


(1)Department of Pathology, County Emergency University Hospital University of Medicine and Pharmacy Craiova
(2)Department of Internal Medicine, County Emergency University Hospital, University of Medicine and Pharmacy, Craiova


Abstract:

Colorectal carcinoma (CRC) represents one of the most common types of carcinoma in both males and females, being encountered mainly in developed countries. North America, Australia/New Zeeland, Western Europe and Japan represent geographic regions with the highest incidence. Approximately 10% of the CRC appear as a result of inherited genetic defects. Lifestyle is undisputedly an important risk factor which influences the apparition of CRC. Alimentation, both quantitatively and qualitatively; alcohol, by inducing cellular proliferation and inhibiting DNA repair as well as smoking, are closely connected with an increase in the risk for CRC. Ulcerative colitis represents a major cause of CRC. The risk for malignization is 2% after 10 years and 18% after 30 years of inflammatory affect. Many of the symptoms of CRC are vague and non-specific (abdominal pain, constipations or diarrhea), some of them being the same in benign pathologies. Recent progresses gave birth to several national screening programs, having a positive effect on the increase in survival rate for CRC patients.


Keywords: Colorectal Carcinoma, Large Bowel, Risk Factors, Screening



Corresponding: CT Streba MD Ph. D. Student, Department of Internal Medicine, County Emergency University Hospital, University of Medicine and Pharmacy Craiova, e-mail: costinstreba@gmail.com


DOI 10.12865/CHSJ.36.04.13 - Download PDF
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