Curr Health Sci J, vol. 36, no. 4, 2010

Epidemiology And Risk Factors In Carcinomas Of The Large Bowel

[Update]

Corina Lavinia Gruia(1), CT Streba(2), Corina Maria Dochita(1), CC Vere(2), AG Ionescu(2)


(1)Department of Pathology, County Emergency University Hospital University of Medicine and Pharmacy Craiova
(2)Department of Internal Medicine, County Emergency University Hospital, University of Medicine and Pharmacy, Craiova;


Abstract:

Colorectal carcinoma (CRC) represents one of the most common types of carcinoma in both males and females, being encountered mainly in developed countries. North America, Australia/New Zeeland, Western Europe and Japan represent geographic regions with the highest incidence. Approximately 10% of the CRC appear as a result of inherited genetic defects. Lifestyle is undisputedly an important risk factor which influences the apparition of CRC. Alimentation, both quantitatively and qualitatively; alcohol, by inducing cellular proliferation and inhibiting DNA repair as well as smoking, are closely connected with an increase in the risk for CRC. Ulcerative colitis represents a major cause of CRC. The risk for malignization is 2% after 10 years and 18% after 30 years of inflammatory affect. Many of the symptoms of CRC are vague and non-specific (abdominal pain, constipations or diarrhea), some of them being the same in benign pathologies. Recent progresses gave birth to several national screening programs, having a positive effect on the increase in survival rate for CRC patients.


Keywords:
Colorectal Carcinoma, Large Bowel, Risk Factors, Screening



Corresponding:
CT Streba MD Ph. D. Student, Department of Internal Medicine, County Emergency University Hospital, University of Medicine and Pharmacy Craiova, e-mail: costinstreba@gmail.com


DOI 10.12865/CHSJ.36.04.13 - Download PDF