CHSJ

Curr Health Sci J, vol. 37, no. 1, 2011

Clinical and Morphological Aspects of Sinovitis in Early Rheumatoid Arthritis

[Original Paper]

B. CAPITANESCU (1), CRISTIANA SIMIONESCU (2), C. MARGARITESCU (2), AL. STEPAN(2), RALUCA CIUREA (2)


(1)Department of Anatomy, University of Medicine and Pharmacy of Craiova;
(2)Department of Pathology, University of Medicine and Pharmacy of Craiova 


Abstract:

The earliest joint changes in rheumatoid arthritis occur in the synovial membrane, leading to development of an unsuppurated proliferative synovitis. This study is based on 33 cases of early rheumatoid arthritis for which we have investigated a series of clinical and morphological parameters. For the examined cases we found that the disease incidence reached its maximum in fifth and sixth decades of life, predominantly in females, over half of cases being diagnosed in the first six months from the onset of the disease. Histopathological study of synovial membrane samples showed characteristic morphological changes but unspecific for the disease, represented by the synoviocytes proliferation, inflammatory infiltrates, fibrinoid necrosis, fibroblasts proliferation and vascular changes. Reaching composite histological score may be useful by providing some information on the severity of the disease


Keywords: early rheumatoid arthritis, clinic, histopathology



Corresponding: Bogdan Capitanescu, MD, PhD Student, Department of Anatomy University of Medicine and Pharmacy of Craiova, Str Petru Rares nr. 4, 200456, Craiova, Dolj, Romania


DOI 10.12865/CHSJ.37.01.03 - Download PDF
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