CHSJ

Curr Health Sci J, vol. 37, no. 1, 2011

Pharmacodynamic and Pharmacokinetic Interactions of Class III Antiarrhythmic Drugs

[For Practitioners]

C.N. VIOREL, FLORICA POPESCU

Department of Pharmacology, University of Medicine and Pharmacy, Craiova


Abstract:

The desirable and undesirable effects of a drug are generally related to its concentration at the sites of action, which in turn is related to the amount administered (dose) and to the drug`s absorption, distribution, metabolism, and/or excretion,  and also drug–drug interactions. The class III antiarrhythmic drugs include amiodarone, sotalol, bretylium, dofetilide, ibutilide and azimilide. Class III antiarrhythmic drugs may interact with other drugs by two major processes: pharmacodynamic and pharmacokinetic interactions. In this review are described the interaction between classes III of antiarrhythmic drugs and other classes antiarrhythmics.


Keywords: antiarrhythmic drugs



Corresponding: C.N. Viorel Md, PhD student, Department of Pharmacology, University of Medicine and Pharmacy, Craiova, Str Petru Rares nr. 4, 200456, Craiova, Dolj, Romania


DOI 10.12865/CHSJ.37.01.08 - Download PDF
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