CHSJ

Curr Health Sci J, vol. 37, no. 4, 2011

Immunological Profile in Patients with Lupus Nephritis and Correlations with the Histological Pattern

[Original paper]

O. DRAKOULOGKONA(1), I. RICA(2), A. BARBULESCU(2), A. MUSETESCU(2), P. CIUREA(2)


(1)Department of Nephrology, „St. Andrews” General State Hospital of Patras-Greece;
(2)Department of Rheumatology, University of Medicine and Pharmacy, Craiova


Abstract:

Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Certain serum autoantibodies are associated with the presence of nephritis. Objective. The aim of the study is to describe and analyse the immunological antibody profile associated with the development of nephritis in patients with systemic lupus erythematosus and to find possible correlations with the histological pattern. Patients and methods. We designed a retrospective case control study of 61 patients with biopsy proven LN and 110 patients with SLE without LN. We used standard methods for laboratory testing of anti-dsDNA, anti-ENA and anti-phospholipid antibodies. Results. Patients with LN were significantly younger at the time of diagnosis ((26.4 (6.4) years versus 35.2 (10.6) years; p<0.001)  A higher frequency of anti-dsDNA, anti-Sm and LA was seen in the group with nephritis (p=0.002; p=0.005; p=0.0001).There were no significant correlations with gender, or the tipe of WHO histological classes identified in patients with lupus nephritis compared with those without renal disease. Conclusions. The factors associated with LN outlined in the current study are the presence of anti-dsDNA, anti-Sm antibodies and of LA


Keywords: lupus nephritis, autoantibody profile, renal biopsy



Corresponding: Paulina Ciurea, Prof, Md, PhD, University of Medicine and Pharmacy of Craiova, , Str Petru Rares nr. 4, 200456, Craiova, Dolj, RomAnia, e-mail: ciureapaulina@yahoo.com


DOI 10.12865/CHSJ.37.04.02 - Download PDF
current issue cover Download cover
Download contents

Journal archive