CHSJ

Curr Health Sci J, vol. 38, no. 1, 2012

The Value of Interleukine 6 in Premature Birth

[Original Paper]

T. DAIANU(1), N. CERNEA(2), A. GOGANAU(2), OANA DAIANU(3), LILIANA NOVAC(2)


(1)Department of Bacteriology–Virusology–Parasitology, University of Medicine and Pharmacy of Craiova;
(2)Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova;
(3)Department of Biochemistry, University of Medicine and Pharmacy of Craiova


Abstract:

The aim of this study was to correlate the levels of interleukin 6 from the cervical-vaginal fluid(IL-6cv), fetal fibronectine (fFN) and the length of the cervical channel (LCC), in the case of women with premature birth risk (PTB) and the superiority of the testing  IL-6cv for 24 hours, an independent predictor of PTB. Material and method The study comprised a number of 64 patients from which 36 pregnant women with PTB risk were selected in order to be evaluated for the determination of the level of IL-6 and fFN in the cervical-vaginal liquid, the exam of vaginal secretion and through trans-vaginal ultrasound in the single pregnancy.  Results and discussionsUnder the presence of bacterial vaginosis, the increase of IL-6cv was correlated with the growth of fFN, test used in order to assess the premature labour. Therefore, we observe that IL-6cv provides a connection between the inflammatory stimulus and delivery, being a key citokine in this process, by increasing its concentration in the cervical-vaginal fluid before the emergence of the clinical signs of birth and the positivisation fFN. Suprisingly, in the case of these pregnant women, the level of IL-6cv has significantly increase in 24 hours from sampling, and this was due to the release of this pro-inflammatory citokin from the cells of the vaginal epitelium. Conclusions IL-6cv and fFN are tests which should be frequently used in the medical practice in order to be able to avoid the immediate and late neonatal complications


Keywords: premature birth, interleukin 6, fetal fibronectine, length of the cervical channel.



Corresponding: T. Daianu, MD, PhD student, Department of Bacteriology-Virusology-Parasitology, University of Medicine and Pharmacy of Craiova, Str Petru Rares nr. 4, 200456, Craiova, Dolj, RomAnia, e-mail: tiberiudaianu@yahoo.com


DOI 10.12865/CHSJ.38.01.03 - Download PDF
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