CHSJ

Curr Health Sci J, vol. 38, no. 2, 2012

The Cellular Source of IL-17A in the Pathogenesis of Inflammatory Joint Diseases

[Review]

I.R. COJOCARU-GOFITA(1), P. CIUREA(1), N.G. YEREMENKO(2)


(1)Rheumatology Department, University of Medicine and Pharmacy  of Craiova, RomAnia;
(2)Department of Clinical Immunology and Rheumatology, ”Academic Medical Center” University of Amsterdam, The Netherlands


Abstract:

Abstract Inflammatory joint diseases comprise a various range of maladies such as: rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis. One of their common  pathogenical features is the implication of TH1/2 cytokines(1). In addition to the well-established TH1 and 2 cytokines there has been  found a new family of cytokines and their receptors – IL-17 - which was thought to be produced mainly by the TH17 subset(1, 2). Recent findings suggest that this highly pro- inflammatory cytokine could be produced by various other cell subtypes such as mast cells(3) (4)and neutrophils. The novelty brought by the intensive research upon IL-17 in human inflammatory joint diseases may bring into clinical practice a broader therapeutical range of options for these patients(5, 6)


Keywords: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; pro- inflammatory cytokines



Corresponding: Cojocaru-Gofita I.R. MD, Ph D Student Rheumatology Department, University of Medicine and Pharmacy of Craiova, RomAnia, Str Petru Rares nr. 4, 200456, Craiova, Dolj, Romania


DOI 10.12865/CHSJ.38.02.01 - Download PDF
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