CHSJ

Curr Health Sci J, vol. 38, no. 3, 2012

Microscopic findings in liver steatosis in HIV-infected children and dead with AIDS

[Original paper]

ANCA-MIHAELA PREDESCU(1), VIOLETA COMANESCU(2), L.MOGOANTA(1), ADRIANA BOLD(1), NINA IONOVICI(1), GAROFITA MATEESCU(1)

  
(1) Histology Discipline, University of Medicine and Pharmacy of Craiova; 
(2) Pathological Anatomy Department, Emergency Clinical Hospital  Craiova


Abstract:

The present histological study followed the presence of liver steatosis in HIV-infected children subsequently dead with AIDS. At autopsy, liver specimens have been sampled from 22 subjects in B and respectively C clinical and immunological stages. The liver specimens have been processed for paraffin embedding, then cut with a microtom into 3-5 micrometer-thick sections, which were stained with haematoxylin-eosin and thricrome Goldner-Szekelly. The presence of liver steatosis was identified in 16 cases (72,8%), in the other 6 cases no steatotic changes being identified. In these 16 cases with presence of liver steatosis, steatosis was graded as follows: mild steatosis in 6 cases (37,5%), moderate steatosis in 4 cases (25%) and severe and massive steatosis in 6 cases (37,5%).The microscopically aspect of liver steatosis, was the most frequently described, as macrovesicular in 8 cases, in 4 cases there were microvesicular changes, and the other 4 cases presented with a mixed aspect, macrovesicular and microvesicular.


Keywords: liver steatosis, HIV, AIDS, lipodystrophy syndrome



Corresponding: Anca-Mihaela Predescu, Teaching Assistant, MD, PhD,,University of Medicine and Pharmacy of Craiova, Str Petru Rares nr. 4, 200456, Craiova, Dolj, Romania, email: medpreses@yahoo.com


DOI 10.12865/CHSJ.38.03.06 - Download PDF
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