CHSJ

Curr Health Sci J, vol. 38, no. 3, 2012

Morphoclinical Correlations In Senile Osteoporosis

[Original paper]

NINA IONOVICI(1), L. MOGOANTA(2), D. GRECU(3), ADRIANA BOLD(2), ANCA MIHAELA PREDESCU(2), CRISTINA BUSUIOC(2), GAROFITA OLIVIA MATEESCU(2)

 
(1)Department of Ocupational Health and Professional Diseases, University of Medicine and Pharmacy of Craiova, 
(2) Department of Histology, University of Medicine and Pharmacy of Craiova, 
(3) Department of Orthopedics, University of Medicine and Pharmacy of Craiova


Abstract:

Osteoporosis is a disease characterized by microarchitectural abnormal changes of bone tissue which lead to fragile bones and bone fractures at medium or minimal traumatism. This disease affects a large population, especially women, proportion women/men being 2/1-3/1. Histologically, the volumes of cortical and spongy bone are reduced in osteoporosis compare to normal bone, bone lost rate been different with bone type and is more accentuated at spongy bone level compare to cortical bone level. One of the most severe complications of senile osteoporosis is the fracture of femoral neck. In our study we concluded that fracture of femoral neck appears to be more frequently in old people, especially in the 7th and 8th decade. Statistic analysis regarding the habitat showed that fracture of femoral neck affects more patients who live in villages because this people are exposed to intense mechanic traumatism. Microscopic study of bone pieces collected from the patients who suffered a surgery for fracture of femoral neck, show a decrease number of bone trabeculaes, thinness, buckling and breaking up of the remaining trabeculaes, parceling disappearing of osteoprogenitors cells from endost, enlarged areolar cavities, distortion and thinning of cortical bone. 


Keywords: osteoporosis, fracture of femoral neck, bone tissue



Corresponding: Nina Ionovici, MD, PhD, University Lecturer,University of Medicine and Pharmacy of Craiova, Str. Petru Rares, nr. 4, 200456, Craiova, Dolj, Romania; e-mail: ninaionovici@yahoo.com


DOI 10.12865/CHSJ.38.03.07 - Download PDF
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