CHSJ

Curr Health Sci J, vol. 39, no. 1, 2013

The value of Doppler cerebral parameters to assess a group of patients with multiple sclerosis

[Original Paper]

A. COTEANU(1), S. GUSTI(2), C. COTEANU(3)


(1)Department of Neurology, Unimed Clinic, Slatina;
(2)Department of Physiology, University of Medicine and Pharmacy of Craiova;
(3)Department of Clinical Laboratory, Clinical Municipal Hospital, Craiova


Abstract:

Background: The current definition of multiple sclerosis is an inflammatory/degenerative disease of central nervous system with focal demyelination around cerebral veins. In 2007 a theory was proposed that demonstrates an alteration of cerebral venous flow in patients with multiple sclerosis. Our study wants to see if there is a statistically significant differences between cerebral venous hemodynamics in multiple sclerosis patients and healthy people. Methods: We admitted in the study twenty-seven patients with multiple sclerois possible or defined, and thirty clinically healthy persons. All subjects underwent neurological assessment and extra-cranial Doppler examination. We calculated for each internal jugular vein a parameter called ?CSA. The sum of all the venous flows was then calculated in clinostatism and in seated position and the difference between the two parameters has been named ?CVF. We assess the eventual presence of reflux in the internal jugular vein after a short period of apnea. Results: Between results of ?CSA parameter were differences with very high statistical significance. Similarly a negative ?CVF is significantly associated with multiple sclerosis. The persisting presence of reflux in internal jugular vein was observed in 60% multiple sclerosis patients. Conclusions: Studied parameters have revealed that there is a hemodynamic significance in the pathology of multiple sclerosis. Thus data obtained led us to the conclusion that the presence of reflux in the internal jugular vein correlated with a negative ?CVF is statistically significant in patients with multiple sclerosis.


Keywords: multiple sclerosis, extra-cranial Doppler, cerebral venous hemodynamics



Corresponding: Aura Coteanu, M.D., Department of Neurology, Unimed Clinic, Slatina, Olt, Romania,Str. Basarabilor, no.16A; e-mail: auracoteanu@yahoo.com


DOI 10.12865/CHSJ.39.01.05 - Download PDF
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